Table 4.

Univariate analysis of clinical risk factors associated with invasive fungal disease free survival

Variable	HR	95% CI	p value
Prophylaxis L-AMB vs. Posaconazole/Micafungin	0.213	0.067–0.680	0.009
Diagnosis (AML vs. ALL)	0.996	0.308–3.216	0.995
HR-ALL vs. LR/IR-ALL	0.990	0.250–3.910	0.988
Relapse	0.349	0.071–1.704	0.193
HSCT	0.721	0.229–2.273	0.577
Age at diagnosis below or above 10 years	3.064	1.061–8.846	0.039
Gender	0.679	0.225–2.051	0.492

Hazard Ratio, 95% confidence intervals and corresponding p-values are reported for each variable

p-values of less than 0.05 indicated statistical significance (in bold)

ALL acute lymphoblastic leukemia, AML acute myeloid leukemia, CI confidence interval, HR Hazard ratio, HR-ALL high risk ALL, HSCT hematopoietic stem cell transplantation, LR/IR-ALL low risk/intermediate risk ALL, IFD invasive fungal disease, L-AMB liposomal amphotericin B