Table 2.

Cox regression analysis of OS in patients with AGC treated with PD-1 inhibitors before propensity score matching

	Univariate		Multivariate
	HR1 (95% CI)1	P value	HR1 (95% CI)1	P value
Gender
Male	1 (Reference)
Female	1.166 (0.689-1.972)	0.567	-	-
Age
≤65	1 (Reference)
>65	0.830 (0.520-1.323)	0.433	-	-
ECOG PS
≤1	1 (Reference)
≥2	0.945 (0.345-2.586)	0.912	-	-
Peritoneum metastasis
Negative	1 (Reference)
Positive	1.782 (1.127-2.816)	0.012	1.183 (0.709-1.974)	0.519
Liver metastasis
Negative	1 (Reference)
Positive	0.812 (0.526-1.255)	0.348	-	-
Lung metastasis
Negative	1 (Reference)
Positive	1.220 (0.707-2.106)	0.475	-	-
Lymph node metastasis
Negative	1 (Reference)
Positive	0.999 (0.649-1.538)	0.997	-	-
Metastasis sites
≤2	1 (Reference)
≥3	2.182 (1.307-3.644)	0.002	2.262 (1.327-3.856)	0.003
Treatment lines
≤2	1 (Reference)
≥3	1.585 (0.976-2.574)	0.060	2.158 (1.290-3.610)	0.003
Treatment types		0.124
Chemotherapy+ targeted therapy	1 (Reference)
Chemotherapy	0.826 (0.504-1.354)	0.449	-	-
Others	1.636 (0.800-3.344)	0.177	-	-
HSP90α
≤82	1 (Reference)
>82	1.921 (1.207-3.059)	0.005	2.229 (1.370-3.627)	0.001
HER-2
Negative/ Unknown	1 (Reference)
Positive	0.462 (0.201-1.063)	0.063	0.545 (0.234-1.266)	0.158
NLR
≤3	1 (Reference)
>3	2.092 (1.357-3.225)	0.001	2.159 (1.383-3.369)	0.001

¹HR = Hazard Ratio, CI = Confidence Interval