Table 1.
Natural plant components for anti-ovarian cancer effects.
| Compound | Formula | Structure | Experiment | Cell types | IC50 | Effect | Reference |
|---|---|---|---|---|---|---|---|
| Kadsuphilactone B | C30H42O5 |
|
In vitro | A2780 | Below 25 μM | Cytotoxic action | 25 |
| Tanshinone IIA | C19H18O3 |
|
In vitro | TOV-21G, SKOV3, OVCAR3 | N/A | Cytotoxic action | 26 |
| Curcumin | C21H20O6 |
|
In vitro | SKOV3 | 24.8μM | Trigger cell cycle arrest, modulating the TIME, DNA damage | 34-37, 96-98 |
| Celastrol | C29H38O4 |
|
In vitro and In vivo | A2780 | 2.11μM | Trigger cell cycle arrest, modulating the TIME, inhibit proliferation, promote apoptosis and suppress cell migration and invasion | 38 |
| SKOV3 | 2.29μM | ||||||
| Berberine | C20H18NO4+ |
|
In vitro | SKOV3 | N/A | ROS damage, promote DNA damage response | 45 |
| Glaucocalyxin B | C22H30O5 |
|
In vitro | A2780 | N/A | ROS damage | 46 |
| Βeta-sitosterol | C29H50O |
|
In vitro | ES2, OV90 | N/A | ROS damage and promote apoptosis | 47 |
| Artemether | C16H26O5 |
|
In vitro and In vivo | SKOV3 | 23.55±3.86μM | ROS damage, regulating apoptosis and ferroptosis | 48-51 |
| HEY1 | 5.80±1.62μM | ||||||
| HEY2 | 7.34±0.56μM | ||||||
| OVCAR8 | 5.51±1.06μM | ||||||
| IGROV-1 | 8.82±1.18μM | ||||||
| OVCAR3 | 14.95±6.38μM | ||||||
| OV-90 | 31.89±4.15μM | ||||||
| TOV-21G | 6.11±0.64μM | ||||||
| Paeonol | C9H10O3 |
|
In vitro and In vivo | A2780, SKOV3 | 1.2mM | Autophagy | 54 |
| Ellagic acid | C14H6O8 |
|
In vitro | SKOV3 | 36.6μM | Induce autophagy, inhibit proliferation and promote apoptosis, suppress cell migration and invasion | 55 |
| Puerarin | C21H20O9 |
|
In vitro and In vivo | SKOV3 | 157.0μg/mL | Inhibit proliferation and promote apoptosis | 59 |
| Caov-4 | 119.3μg/mL | ||||||
| Quercetin | C15H10O7 |
|
In vitro | PA-1 | N/A | Suppress cell migration and invasion | 64 |
| Fraxetin | C10H8O5 |
|
In vitro | SKOV3, SW626 | N/A | Suppress cell migration and invasion | 65 |
| Dihydroartemisinin | C15H24O5 |
|
In vitro | OVCAR3, SKOV3, A2780, OV-56 | 80μmol/L | Suppress cell migration and invasion, inhibit proliferation | 66 |
| Proanthocyanidins | Compound |
|
In vitro | A2780/CP70 | N/A | Inhibit angiogenesis | 71 |
| Baicalein | C15H10O5 |
|
In vitro and In vivo | SKOV3 | N/A | Inhibit angiogenesis and proliferation, autophagy | 72, 73 |
| Theasaponin E1 | C59H90O27 |
|
In vitro | OVCAR-3 | 3.5μM | Inhibit angiogenesis and proliferation | 70 |
| A2780/CP70 | 2.8μM | ||||||
| Triptolide | C20H24O6 |
|
In vitro and In vivo | SKOV3/DDP | N/A | Suppress cell migration and invasion | 80 |