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. 2025 Jul 24;16(11):3415–3424. doi: 10.7150/jca.110306

Figure 2.

Figure 2

Target genes between PsO and SKCM. (A) Venn diagram showing the overlap of all three groups. HLA-DOB is highlighted as a key gene in the intersection.'Skin Sun Exposed VS GWAS' presents genes identified from the conjunction analysis between eQTL data from 'GTEx V7 Sun Exposed (Lower leg)' and PsO GWAS data 'ebi-a-GCST90018907'.'Skin Not Sun Exposed VS GWAS' presents genes identified from the conjunction analysis between eQTL data from 'GTEx V7 Not Sun Exposed (Suprapubic)' and PsO GWAS data 'ebi-a-GCST90018907'.'Differential Genes (SKCM/Normal) TCGA'presents genes DEGs between SKCM and normal tissue form TCGA database. (B) Volcano plot illustrating differentially expressed genes between SKCM and normal tissue form TCGA database. (C) Kaplan-Meier survival curve comparing overall survival rates between high and low HLA-DOB expression groups in SKCM patients. (D) The expression of HLA-DOB by immunohistochemistry analysis in psoriasis patients and SKCM patients.