Table 1.
Mechanisms and Effects of pharmacological compounds on H3K14 modification
| Name of Drug Compound |
Mechanism of action | Results | References |
|---|---|---|---|
| Ochratoxin A (OTA) | Mediates downregulation of acetylation genes | Loss of acetylation at H3K14 |
73 |
| Hydroxamic acid derivative CTS203 | Inhibition of HDAC activity | H3K14ac goes up | 74 |
| Isoniazid (INH) | Increased expression of HDAC1 and HDAC2 | H3K14ac decreases and SOD activity decreases |
75 |
| Scriptaid | Scriptaid inhibits the expression of the HDAC5 gene | H3K14ac goes up | 76 |
| Butyrate | Inhibition of HDAC | H3K14ac goes up | 77 |
| Valproate (VPA) | Activation of BDNF-TrkB signaling pathway and inhibition of HDAC | H3K14ac goes up | 78, 79 |
| Compound 511 | The mRNA expression of HDAC1/6/8 was up-regulated | Inhibits morphine-induced H3K14 hyperacetylation | 80 |
| Bisphenol A (BPA) | Enhanced HDAC2 expression | Reduces histone acetylation of the StAR promoter | 81 |
| LPC | Up-regulated KAT2A, KAT5, and KAT9 | H3K14ac goes up | 16 |
| Melatonin | Activation of CREB-binding protein (CBP) /p300 histone acetyltransferase activity via ERK signaling pathway | H3K14ac goes up | 82 |
| Osthole | Upregulation of MOZ and MORF | H3K14ac goes up | 83 |
| Conjugated bile acids (CBAs) | Hdacs inhibited by pernuclear s1p; And affect the CCAS-S1PR2-nuclear SphK2-S1KP signaling pathway | H3K14ac goes up | 84 |
| Green tea catechin epigallocatechin-3-gallat (EGCG) | The expression of DNMT1, HDAC1, HDAC2 and G9a was down-regulated | Enhanced and acetylated H3K14 binding to p27, PCAF, C/EBPα and C/EBPɛ promoter regions | 85 |
| Pomegranate seed Oil (PSO) | Increase IGF-1 levels | Acetylated H3K14 was enriched at the IGF-1 gene promoter | 86 |
| 20(S)-ginsenoside Rh2 (Rh2) | Inhibition of total HDAC activity and induction of MAPK signaling | H3K14ac goes up | 87 |
| Black Mulberry Extract (BME) | Inhibition of total HATs and p300 activities in vitro | H3K14ac goes down | 88 |
| Paeonol | Weak h2o2 -induced upregulation of lysine deacetylase activity of Sirt1 | H3K14ac goes down | 89 |
| Blueberry treatment | Regulates histone acetylation | 90 | |
| Chp2 protein | Binds to the SHREC histone deacetylase complex (SHREC2) | H3K14ac goes down | 91 |
| Protein Fbxw15 | Mediates HBO1/KAT7 ubiquitination and degradation | It regulates acetylation of histone H3K14 | 92 |
| Dmp53 | Required for the maintenance of basal H3-K14 acetylation levels in Drosophila chromatin | Maintain H3K14 acetylation levels | 93 |