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. 2025 Jul 24;16(11):3329–3342. doi: 10.7150/jca.115892

Figure 2.

Figure 2

(A) Pattern: CDC42 regulates phosphorylation of paxillin to promote expression of cathepsin B/D. The brown beaded structure is collagen, the yellow structure is elastin, and the blue branched structure is glycosaminoglycan and proteoglycan. (B) Western blot results of Y118-paxillin, paxillin, S397-FAK, FAK, Integrin β1, cathepsin B/D and CDC42 protein expression in LoVo and HCT116 cells before and after treatment. (C) Western blot results of CDC42, integrin β1, Y118-paxillin, paxillin, S397-FAK, FAK and cathepsin B/D protein expression before and after transfection with siRNA-CDC42 in LoVo PDCs and HCT116 PDCs. (D) Western blot results of CDC42, integrin β1, Y118-paxillin, paxillin, S397-FAK, FAK and cathepsin B/D protein expression before and after ML141 intervention in LoVo PDCs and HCT116 PDCs. (E) Western blot results of integrin β1, Y118-paxillin, paxillin, S397-FAK, FAK, cathepsin B/D and CDC42 protein expression before and after transfection with siRNA- integrin β1 in LoVo PDCs and HCT116 PDCs.