Table 2.
Comparison of lipid species between controls and cases.
| Lipid species (nmol/ml) | Control [Median (interquartile range)] (n = 13) | Cases [Median (interquartile range)] (n = 17) | p-value | FDR |
|---|---|---|---|---|
| Dihydroceramides | ||||
| dhCer 18:0;O2/16:0 | 0.030 (0.0026–0.031) | 0.032 (0.025–0.043) | 0.05 | 0.15 |
| dhCer 18:0;O2/18:0 | 0.013 (0.010–0.017) | 0.015 (0.011–0.024) | 0.14 | 0.23 |
| dhCer 18:0;O2/20:0 | 0.007 (0.006–0.010) | 0.010 (0.008–0.015) | 0.04 | 0.15 |
| dhCer 18:0;O2/22:0 | 0.032 (0.024–0.038) | 0.042 (0.031–0.073) | 0.05 | 0.15 |
| dhCer 18:0;O2/24:0 | 0.045 (0.036–0.054) | 0.059 (0.042–0.089) | 0.04 | 0.15 |
| dhCer 18:0;O2/24:1 | 0.029 (0.019–0.043) | 0.035 (0.027–0.064) | 0.11 | 0.21 |
| Total dihydro ceramides | 0.152 (0.127–0.198) | 0.202 (0.148–0.310) | 0.06 | 0.15 |
| Ceramides | ||||
| Cer 18:1;O2/16:0 | 0.25 (0.22–0.31) | 0.28 (0.26–0.34) | 0.10 | 0.21 |
| Cer 18:1;O2/18:0 | 0.07 (0.05–0.08) | 0.08 (0.07–0.11) | 0.02 | 0.12 |
| Cer 18:1;O2/20:0 | 0.07 (0.05–0.07) | 0.08 (0.07–0.10) | 0.01 | 0.12 |
| Cer 18:1;O2/22:0 | 0.82 (0.75–0.92) | 1.04 (0.78–1.34) | 0.06 | 0.15 |
| Cer 18:1;O2/24:0 | 2.2 (2.04–2.56) | 2.77 (2.40–3.56) | 0.02 | 0.12 |
| Cer 18:1;O2/24:1 | 0.83 (0.67–1.19) | 1.1 (0.84–1.15) | 0.14 | 0.23 |
| Total Ceramides | 4.54 (3.89–4.88) | 5.41 (4.57–6.81) | 0.02 | 0.12 |
| Dihydrosphingomyelins | ||||
| dhSM 18:0;O2/16:0 | 4.82(4.04–5.80) | 5.36 (4.61–6.26) | 0.28 | 0.41 |
| dhSM 18:0;O2/18:0 | 0.91 (0.57–1.46) | 1.37 (0.89–2.06) | 0.10 | 0.21 |
| dhSM 18:0;O2/20:0 | 0.35 (0.27–0.46) | 0.48 (0.39–0.83) | 0.02 | 0.12 |
| dhSM 18:0;O2/22:0 | 0.35 (0.29–0.50) | 0.54 (0.39–0.98) | 0.02 | 0.12 |
| dhSM 18:0;O2/24:0 | 0.09 (0.07–0.12) | 0.13 (0.10–0.21) | 0.04 | 0.15 |
| dhSM 18:0;O2/24:1 | 1.22 (0.94–1.50) | 1.47 (1.21–2.05) | 0.07 | 0.17 |
| Total Dihydrosphingomyelins | 7.7 (6.45–10.01) | 9.20 (7.52 −13.45) | 0.08 | 0.19 |
| Sphingomyelins | ||||
| SM 18:1;O2/16:0 | 172.3 (143.3 −184.50) | 171.60 (141.70 −181.50) | 0.87 | 0.87 |
| SM 18:1;O2/18:0 | 23.92 (17.71–25.45) | 23.92 (21.78–28.68) | 0.30 | 0.42 |
| SM 18:1;O2/20:0 | 23.40 (21.0–21.53) | 26.59 (21.44–32.66) | 0.13 | 0.23 |
| SM 18:1;O2/22:0 | 47.91 (41.54–58.87) | 52.59 (42.82–68.17) | 0.51 | 0.60 |
| SM 18:1;O2/24:0 | 32.81 (28.15–40.63) | 32.14 (27.01–54.72) | 0.68 | 0.72 |
| SM 18:1;O2/24:1 | 70.74 (54.69–74.96) | 69.87 (62.46–83.99) | 0.53 | 0.62 |
| Total Sphingomyelins | 374.90 (315.30–403.90) | 372.9 (325.20–440.60) | 0.48 | 0.59 |
| Hexosylceramides | ||||
| Hex-Cer 18:1;O2/16:0 | 0.67 (0.55–0.76) | 0.57 (0.44–0.80) | 0.62 | 0.69 |
| Hex-Cer 18:1;O2/18:0 | 0.07 (0.05–0.07) | 0.06 (0.04–0.07) | 0.43 | 0.57 |
| Hex-Cer 18:1;O2/20:0 | 0.06 (0.04–0.07) | 0.04 (0.03–0.06) | 0.36 | 0.49 |
| Hex-Cer 18:1;O2/22:0 | 0.50 (0.42–0.64) | 0.42 (0.31–0.59) | 0.18 | 0.28 |
| Hex-Cer 18:1;O2/24:0 | 0.62 (0.55–0.67) | 0.52 (0.34–0.78) | 0.48 | 0.59 |
| Hex-Cer 18:1;O2/24:1 | 0.38 (0.31–0.42) | 0.38 (0.22–0.43) | 0.80 | 0.83 |
| Total Hexosylceramides | 2.35 (2.07–2.60) | 2.00 (1.46–2.86) | 0.68 | 0.72 |
| Diacylglycerols | 33.20 (29.20–44.20) | 51.20 (43.60–83.38) | 0.0009 | 0.02 |
| Phosphatidylcholines | 1184 (1125–1324) | 1275 (1190—1548) | 0.13 | 0.23 |
| Triacylglycerols | 531.7 (380.7–658.9) | 789.6 (643.6–1695) | 0.0004 | 0.02 |
Cer, Ceramides; HexCer, Hexosylceramides; dhSM, dihydrosphingomyelins; SM, sphingomyelins. Data show median with interquartile range. Wilcoxon rank sum test was performed to estimate significance in difference in lipid species between two groups. Bold represents statistically significant difference between controls and cases.