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. 2025 Aug 23;15:31031. doi: 10.1038/s41598-025-15778-z

Table 4.

Correlation between lipid species with BMI and 24-h insulin dose.

Lipid species (nmol/ml) BMI Insulin dose
r P-value r P-value
Dihydroceramides
dhCer 18:0;O2/16:0 0.29 0.12 0.26 0.16
dhCer 18:0;O2/18:0 0.34 0.07 0.22 0.23
dhCer 18:0;O2/20:0 0.54 0.002 0.38 0.03
dhCer 18:0;O2/22:0 0.49 0.005 0.41 0.02
dhCer 18:0;O2/24:0 0.46 0.01 0.52 0.003
dhCer 18:0;O2/24:1 0.42 0.02 0.23 0.22
Total Dihydroceramides 0.47 0.008 0.41 0.02
Ceramides
Cer 18:1;O2/16:0 0.28 0.12 0.47 0.008
Cer 18:1;O2/18:0 0.42 0.02 0.41 0.02
Cer 18:1;O2/20:0 0.39 0.03 0.52 0.003
Cer 18:1;O2/22:0 0.31 0.08 0.66  < 0.0001
Cer 18:1;O2/24:0 0.33 0.07 0.67  < 0.0001
Cer 18:1;O2/24:1 0.25 0.17 0.30 0.09
Total Ceramides 0.34 0.06 0.65  < 0.0001
Dihydrosphingomyelins
dhSM 18:0;O2/16:0 0.46 0.01 −0.04 0.82
dhSM 18:0;O2/18:0 0.46 0.01 0.15 0.45
dhSM 18:0;O2/20:0 0.58 0.008 0.36 0.04
dhSM 18:0;O2/22:0 0.60 0.004 0.40 0.03
dhSM 18:0;O2/24:0 0.54 0.002 0.40 0.03
dhSM 18:0;O2/24:1 0.50 0.004 0.24 0.20
Total Dihydrosphingomyelins 0.51 0.004 0.08 0.67
Sphingomyelins
SM 18:1;O2/16:0 0.27 0.14 0.04 0.80
SM 18:1;O2/18:0 0.38 0.04 0.04 0.81
SM 18:1;O2/20:0 0.46 0.01 0.31 0.09
SM 18:1;O2/22:0 0.33 0.07 0.18 0.32
SM 18:1;O2/24:0 0.22 0.25 0.18 0.35
SM 18:1;O2/24:1 0.40 0.02 −0.04 0.86
Total Sphingomyelins 0.38 0.03 0.08 0.67
Hexosylceramides
Hex-Cer 18:1;O2/16:0 0.15 0.42 −0.04 0.82
Hex-Cer 18:1;O2/18:0 −0.07 0.73 −0.28 0.14
Hex-Cer 18:1;O2/20:0 −0.09 0.62 −0.08 0.69
Hex-Cer 18:1;O2/22:0 −0.08 0.66 −0.08 0.68
Hex-Cer 18:1;O2/24:0 −0.09 0.62 −0.13 0.48
Hex-Cer 18:1;O2/24:1 0.02 0.88 −0.17 0.36
Total Hexosylceramides 0.05 0.79 −0.04 0.82
Diacylglycerols 0.53 0.002 0.44 0.01
Phosphatidylcholines 0.24 0.20 0.23 0.21
Triacylglycerols 0.52 0.003 0.40 0.03

r = Spearman correlation coefficient; bold represents significant correlation.