Table 1.

Writers, readers, and erasers of lactylation.

Writers	Erasers	Readers
1) KATs	1) Zn2+ dependent:	BRG1
P300/CBP family (P300, CBP)	Class I (HDAC1–3 and 8)	DPF2
GNAT family (GCN5/KAT2A, YiaC)	Class II (II b: HDAC 6)	TRIM33
MYST family (MOF/KAT8, TIP60/KAT5, HBO1/KAT7)	2) NAD+ dependent:
2) AARSs family (AARS1, AARS2)	Class III (SIRT1–3, 6, and CobB)
3) Others (ATAT1, ACAT2, ESCO2, NAA10, HDAC6)

KATs Lysine acyltransferases, CBPCREB-binding protein, GNAT GCN5-related N-acetyltransferase, MYST Moz-Ybf2/Sas3-Sas2-Tip60, TIP60 Tat-interactive protein 60, KAT (lysine acetyltransferase), MOF (males absent on the first), HBO1 (histone acetyltransferase binding to ORC1), ATAT1 (α-tubulin acetyltransferase 1), ESCO2 (establishment of sister chromatid cohesion N-acetyltransferase 2), NAA10 N-α-acetyltransferase 10, AARS alanyl-tRNA synthetase, HDAChistone deacetylase, SIRTs (Sirtuins), TRIM33 (tripartite motif containing 33), DPF2 (double PHD finger 2), BRG1 (Brahma-related gene 1).