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. 2025 Aug 24;8:543. doi: 10.1038/s41746-025-01955-x

Table 4.

Diagnostic accuracy on the GMDB set

Dataset Model Vanilla LLMs Cypher RAG LLMs Vector RAG LLMs

GMDB set

selective test

GPT-3.5-turbo 59.20 65.20 71.20
GPT-4-turbo 85.20 87.00 88.80
GPT-4o 89.20 91.00 92.80
Claude-3-opus 81.20 85.40 89.60
Claude-3-sonnet 63.20 74.80 86.40
Claude-3-haiku 71.20 77.80 84.20
Gemini-pro 51.20 43.00 66.80
LLaMA-70b 70.60 75.40 80.00
Average 71.38 74.95 82.48

GMDB set

non-selective test

GPT-3.5-turbo 38.40 44.60 50.80
GPT-4-turbo 46.20 57.60 69.00
GPT-4o 48.00 59.80 71.60
Claude-3-opus 52.80 63.80 74.80
Claude-3-sonnet 45.60 58.20 70.60
Claude-3-haiku 46.20 58.00 69.80
Gemini-pro 22.40 0.80 49.80
LLaMA-70b 34.80 43.60 52.60
Average 41.80 48.30 63.63

Vector RAG delivers the strongest performance, boosting average accuracy by 11.10% (selective) and 21.83% (non-selective) over vanilla LLMs, with GPT-4o achieving the highest accuracy of 92.80%. Notably, non-selective tests show a steeper performance gap, underscoring RAG’s value in challenging scenarios. The bold values represent the best performance among these three methods.