Table 1.
Cas protein prediction accuracy using different models
| 650 million ESM | 15 billion ESM | CasIdentifier HMM + ML | HMMCAS HMM | CASPredict SVM | |
|---|---|---|---|---|---|
| Cas1 | 98.5% | 98.5% | 99.5% | 97.4% | 70.8% |
| Cas2 | 96.3% | 99.4% | 96.9% | 94.4% | 73.8% |
| Cas3 | 98.1% | 98.7% | 98.1% | 97.7% | 66.3% |
| Cas4 | 89.9% | 94.4% | 92.1% | 96.6% | 65.2% |
| Cas5 | 97.7% | 98.5% | 93.1% | 82.3% | 61.5% |
| Cas6 | 99.0% | 98.7% | 99.4% | 98.1% | 61.5% |
| Cas7 | 100.0% | 100.0% | 100.0% | 95.5% | 77.3% |
| Cas8 | 88.9% | 100.0% | 100.0% | 88.9% | 77.8% |
| Cas9 | 100.0% | 100.0% | 98.7% | 99.3% | 91.4% |
| Cas10 | 99.6% | 99.6% | 99.2% | 99.6% | 82.3% |
| Cas12 | 100.0% | 100.0% | 97.4% | 39.5% | 76.3% |
| Cas13 | 100.0% | 100.0% | 100.0% | N.A. | 93.3% |
| Non-Cas | 99.8% | 99.9% | 96.5% | N.A. | 75.2% |