Table 2.

Cas12a protein trans-cleavage activity prediction accuracy using different strategies

Best model + covariates	Accuracy in test set
LightGBM [1] + embeddings	69.2%
CatBoost [2] + PCA-2	69.2%
CatBoost [2] + PCA-3	84.6%
CatBoost [2] + PCA-4	92.3%
CatBoost [2] + PCA-5	84.6%
LightGBM [1] + PCA-6	92.3%
CatBoost [2] + PCA-7	76.9%
RandomForest [3] + PCA-8	92.3%
Neural Network [4] + PCA-9	84.6%
CatBoost [2] + PCA-10	76.9%
CatBoost [2] + PCA-11	84.6%
CatBoost [2] + PCA-12	69.2%
CatBoost [2] + PCA-13	69.2%
CatBoost [2] + PCA-14	84.6%
Neural Network [4] + PCA-15	69.2%