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. 2025 Aug 23;8:1269. doi: 10.1038/s42003-025-08707-3

Table 1.

Transcriptomic differences between PKH2hi and PKH2low macrophages of genes that are down-regulated upon Ly6C+ monocytes conversion to the Ly6C- phenotype32

Gene PKH2hi Macrophages PKH2low Macrophages Fold change (log 2) Q value
Cebpe 1.84625 1.71813 22.1857 37.3552 4.06216 0.000617
Ly6c2 20.0821 18.7825 174.77 287.827 3.57323 0.000617
Mmp8 3.07353 17.9474 49.5149 124.769 3.05154 0.000617
Sell 29.9319 36.0813 135.501 277.244 2.64443 0.000617
Ccr2 82.7926 124.046 439.597 491.833 2.17094 0.000617
Fcrls 4.02183 3.35151 10.1622 8.24292 1.31972 0.011855
Foxm1a 3.69174 3.96529 0.537529 0.565516 −2.79529 0.004085

Only genes whose expression was downregulated in both the bone marrow and blood are displayed. Table 1 depicts genes that changed dramatically ( > 2-fold change) and in a statistically significant manner (Q < 0.05).

aFoxm1 reduction in blood monocytes8 was minimal.