Table 3.
Parameters used in the model (Continued from Table 2)
| Parameter | Description | Dimensional Value | References |
|---|---|---|---|
| Conversion parameters of T cell | |||
| a1 | Conversion rate of activated effector T cell to exhausted effector T cell | 1.67 × 10−4s−1 | Estimated |
| b1 | Conversion rate of exhausted effector T cell to activated effector T cell | 5.56 × 10−5s−1 | Estimated |
| HC | Hill coefficient in T cell conversion | 1.2 μM | Estimated |
| Binding parameters | |||
| k1 | Association rate | 1.2 × 10−3 μM−1s−1 | 63 |
| k−1 | Dissociation rate | 1.8 × 10−3s−1 | 63 |
| CAF phenotypic parameters | |||
| α | Antiimmune rate | [0, 1]* | Varied throughout the study |
| β | Proimmune rate | [0, 1]* | Varied throughout the study |
| γ | Anticancer rate | [0, 1]* | Varied throughout the study |
| δ | Procancer rate | [0, 1]* | Varied throughout the study |
Parameters labeled as ‘Estimated’ are not directly measured in experiments but are inferred through simulations to ensure biologically plausible system behavior. These estimations are based on known biological timescales, qualitative observations, or values reported in related literature. Dimensionless values are marked in *.