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. Author manuscript; available in PMC: 2025 Aug 25.
Published in final edited form as: Placenta. 2025 Jun 6;168:35–45. doi: 10.1016/j.placenta.2025.05.029

Fig. 2. Gene expression of glucose metabolism-related factors in BeWo cells following 24 h culture in no FBS media and 20 h of sham or insulin-like 1 growth factor (hIGF1) nanoparticle treatment.

Fig. 2.

A. Gene expression of glucose transporter SLC2A1 in − FBS − hIGF1 BeWo cells was similar to + FBS − hIGF1 BeWo cells but trended for an increase when compared to − FBS + hIGF1 BeWo cells. B. Gene expression of gluconeogenesis enzyme G6PC was increased in − FBS − hIGF1 and − FBS + hIGF1 BeWo cells compared to + FBS − hIGF1. C. PCK2 expression was increased in − FBS + hIGF1 BeWo cells compared to + FBS − hIGF1 and − FBS − hIGF1. D. FBP1 expression was increased in − FBS + hIGF1 BeWo cells compared to + FBS − hIGF1 and − FBS − hIGF1. E. Gene expression of glycolysis enzymes HK2 was similar between + FBS − hIGF1 and − FBS − hIGF1 BeWo cells but increased in − FBS + hIGF1. F. Gene expression of PFKP was similar between + FBS − hIGF1 and − FBS − hIGF1 BeWo cells but increased in − FBS + hIGF1. G. Gene expression of LDHA was similar between + FBS − hIGF1 and − FBS − hIGF1 BeWo cells but increased in − FBS + hIGF1. H. Expression of LDHB was increased in − FBS − hIGF1 and − FBS + hIGF1 BeWo cells compared to + FBS − hIGF1. I. Expression of LDHC was increased in − FBS − hIGF1 and − FBS + hIGF1 BeWo cells compared to + FBS − hIGF1. Data are estimated marginal mean ± SEM calculated using generalized linear modelling. n = 12 independent passages. *P < 0.05; **P < 0.01; ***P < 0.001. SLC2A1: solute carrier family 2 member 1. G6PC: glucose-6-phosphatase. FBP1: Fructose-1,6-bisphosphatase 1. PCK2: Phosphoenolpyruvate carboxykinase 2. HK2: hexokinase 2. PFKP: Phosphofructokinase, platelet. LDHA/B/C: lactate dehydrogenase A/B/C.