TABLE 3.
Range of phthalate metabolites and summary phthalate measures for study participants in the Midlife Women’s Health Study
| Phthalates |
MWHS (n = 762) |
NHANES 2005-2006 (all females; n = 1,278) |
NHANES 2007-2008 (all females; n = 1,310) |
||
|---|---|---|---|---|---|
| Parent | Metabolite | % ≥ LOD | Mediana (95% CI) | Median (95% CI) | |
| DEHP | MEHHP | 100 | 33.3 (30.9-36.2) | 21.4 (19.5-23.4) | 19.9 (16.8-23.3) |
| MEHP | 100 | 4.5 (4.2-5.0) | 2.10 (1.90-2.40) | 2.00 (1.70-2.40) | |
| MEOHP | 100 | 11.95 (11.2-12.5) | 13.8 (12.5-15.7) | 11.7 (9.80-13.5) | |
| MECPP | 100 | 25.6 (23.9-28.0) | 31.7 (28.0-36.6) | 31.0 (26.4-38.3) | |
| DnOP | MCPP | 100 | 2.53 (2.3-2.77) | 1.80 (1.60-2.10) | 2.60 (2.30-3.00) |
| BBzP | MBzP | 100 | 9.25 (8.5-9.9) | 7.70 (6.55-9.36) | 7.99 (6.41-9.36) |
| DEP | MEP | 99 | 96.95 (87.6-107) | 109 (86.8-130) | 82.4 (67.6-101) |
| DBP | MBP | 100 | 19.8 (18.5-21.3) | 20.4 (17.1-24.7) | 20.8 (18.1-23.2) |
| DiBP | MiBP | 100 | 16.25 (15.3-17.3) | 5.50 (4.70-6.60) | 7.40 (6.50-8.30) |
| Summary phthalates b | Median (IQR) | ||||
| sumPCP | 2.05 (1.00, 3.10) | ||||
| sumDEHP | 0.34 (0.24, 0.54) | ||||
| sumAA | 0.69 (0.52, 0.94) | ||||
| sumPLASTIC | 0.43 (0.31, 0.63) | ||||
| sumALL | 2.54 (1.54, 3.73) | ||||
AA, antiandrogenic; BBzP, benzyl butyl phthalate; CI, confidence interval; DBP, dibutyl phthalate; DEHP, di-(2-ethylhexyl) phthalate; DEP, diethyl phthalate; DiBP, diisobutyl phthalate; DnOP, dioctyl phthalate; IQR, interquartile range; LOD, level of detection; MBP, monobutyl phthalate; MBzP, monobenzyl phthalate; MCEPP, mono-(5-carboxy-2-ethylpentyl) phthalate; MCPP, mono-(3-carboxypropyl) phthalate; MEHHP, mono-(2-ethyl-5-hydroxyhexyl) phthalate; MEHP, monoethylhexyl phthalate; MEOHP, mono-(2-ethyl-5-oxohexyl) phthalate; MEP, monoethyl phthalate; MiBP, monoisobutyl phthalate; MWHS, Midlife Women’s Health Study; NHANES, National Health and Nutrition Examination Survey; PCP, personal care products.
ng/mL adjusted for specific gravity.
Summary phthalate measures were calculated as follows:.
sumPCP is the sum of phthalate metabolites present in personal care products: MBP + MEP.
sumDEHP is the sum of DEHP metabolites: MECPP + MEHHP + MEHP + MEOHP.
sumAA is the sum of phthalate metabolites with known androgenic activity: sumDEHP + MBP + MBzP + MiBP.
sumPLASTIC is the sum of phthalate metabolites from plastic sources: sumDEHP + MCPP + MBzP.
sumALL is the sum of all calculated phthalate metabolites: sumDEHP + MCPP + MBzP + MEP + MBP + MiBP.