. Author manuscript; available in PMC: 2025 Aug 25.

Published in final edited form as: Toxicol In Vitro. 2019 Oct 16;62:104669. doi: 10.1016/j.tiv.2019.104669

Table 3.

IC₅₀ values of ADQ in HepG2 cell lines overexpressing human CYPs.^a

	IC₅₀ (μM)	95% confidence intervals (μM)
CYP vector	17.1	15.7–18.6
CYP1A1	26.4^*	25.6–27.3
CYP1A2	18.7	17.2–20.2
CYP1B1	25.7^*	24.0–27.6
CYP2C8	11.7^*	10.1–13.4
CYP2C19	17.3	13.0–23.1
CYP3A4	14.0^*	13.0–15.1
CYP3A5	17.1	15.4–18.9

HepG2 cell lines overexpressing human CYPs were incubated with various concentrations of ADQ (1.56–50 μM) for 48 h. The IC₅₀ values were obtained from the cell growth curves, using GraphPad Prism 6.0. Data are presented as the mean IC₅₀ of three independent experiments and 95% confidence intervals of the IC₅₀.

Significantly (p < .05) different from CYP vector cells.