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. Author manuscript; available in PMC: 2025 Aug 25.
Published in final edited form as: J Phys Chem Lett. 2025 Jul 25;16(31):7797–7806. doi: 10.1021/acs.jpclett.5c01627

Figure 2.

Figure 2.

Internal structures of condensates formed by TDP-43 LCD. (A) Number of peptides in condensates as a function of simulation time at T = 0.58 kcal/mol·kB for WT TDP-43 LCD. (B) Evolution of peptides in contact with the randomly selected peptide. (C) Number of residue contacts between randomly selected peptide and the rest peptides. (D) Time-averaged contact probability of each peptide with randomly selected peptide. (E) Radial distribution function of coarse-grained beads in the condensates of TDP-43. (F) The radius of gyration distributions of peptides in the dilute and condensed phases differ significantly (Kruskal-Wallis test, p ~ 1e-12).