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. Author manuscript; available in PMC: 2025 Aug 25.
Published in final edited form as: J Phys Chem Lett. 2025 Jul 25;16(31):7797–7806. doi: 10.1021/acs.jpclett.5c01627

Figure 3.

Figure 3.

Small-world network structure of the condensates formed by TDP-43 LCD at T = 0.56 kcal/mol·kB. and the concentration of the condensed phase was and 0.01 nm−3. (A) Distribution of peptide connections. (B) Network graph of a typical condensate formed by TDP-43 LCD. (C) Cumulative probability, CP(n), defined as the fraction of a peptide having at least n connections. (D) Representative conformation of a peptide with a large valence. Right-top panel: overall conformation of a condensate. The peptides in the simulation box are shown in cyan with the neighboring peptides in gray to illustrate the periodic boundary conditions; Right-bottom panel: conformation of the condensate in the simulation box. Left-bottom panel: zoom-in conformation of the peptide possessing a large valence. The peptide of a large valence is shown in red, and the connected peptides are shown in green.