Fig. 1.

Apoptosis is observed in mouse Sertoli TM4 cells after CBD exposure for 48 h. Mouse Sertoli TM4 cells were treated with DMSO or the indicated CBD concentrations for 24 h or 48 h. (A) Representative scatter plots show the flow cytometric results for Annexin V/PI staining after CBD treatment for 24 h and 48 h. (B & C) Quantification of Annexin V/PI staining results. Bar graphs show the mean percentage of viable, early apoptotic, or late apoptotic cells ± SD (n = 3). *, p < 0.05, significantly different from the DMSO control.