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. Author manuscript; available in PMC: 2025 Aug 25.
Published in final edited form as: Toxicology. 2025 Jan 31;512:154068. doi: 10.1016/j.tox.2025.154068

Fig. 4.

Fig. 4.

Comparison of pathway enrichment in CBD-treated mouse Sertoli TM4 cells with primary human Sertoli cells using IPA. Left side shows heatmap visualization of top 20 canonical pathways changed in a concentration-dependent manner in mouse Sertoli TM4 cells, based on DEGs from 10 – 20 μM CBD treatment. Right side shows corresponding changes in the same pathways in CBD-treated primary human Sertoli cells. Blue represents down-regulated pathways and orange represents up-regulated pathways. A z-score threshold of ± 2 was used to infer significant up-regulation or down-regulation. When the absolute z-score is below 2, the alterations in gene expression within the pathway do not strongly indicate a distinct pattern.