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. Author manuscript; available in PMC: 2025 Aug 25.
Published in final edited form as: Toxicology. 2025 Jan 31;512:154068. doi: 10.1016/j.tox.2025.154068

Fig. 6.

Fig. 6.

Prediction of upstream regulators in CBD-treated mouse Sertoli TM4 cells and primary human Sertoli cells using IPA. Heatmap visualization of top 25 predicted upstream regulators in (A, left side) mouse Sertoli TM4 cells and (B, left side) primary human Sertoli cells from DGEs across various CBD treatments. Right sides in A and B show corresponding changes in the same upstream regulators in CBD-treated primary human Sertoli cells (A, right side) and mouse Sertoli TM4 cells (B, right side). An overlapped top upstream regulator between mouse Sertoli TM4 cells and primary human Sertoli cells is underlined. Blue represents down-regulation and orange represents up-regulation.