Table 2.
Gene expressions that relevant to the function of Sertoli cells.
| Primary human Sertoli cells | Mouse Sertoli TM4 cells | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene name | Base mean* of control | Base mean of 10 µM CBD | Log2 fold change# | Adjusted p value | Gene name | Base mean* of control | Base mean of 20 µM CBD | Log2 fold change# | Adjusted p value |
| LHCGR | 0 | 0 | NA | NA | Lhcgr | NA | NA | NA | NA |
| CYP11A1 | 17.79 | 13.02 | −0.45 | 0.50 | Cyp11a1 | 2.61 | 0 | −0.024 | NA |
| HSD3B1 | 0 | 0 | NA | NA | Hsd3b1 | NA | NA | NA | NA |
| CYP17A1 | 0 | 0 | NA | NA | Cyp17a1 | NA | NA | NA | NA |
| HSD17B3 | 0 | 0 | NA | NA | Hsd17b3 | NA | NA | NA | NA |
| SRD5A1 | 1144.88 | 919.23 | −0.32 | 2.42E—05 | Srd5a1 | 1358.20 | 699.66 | −0.90 | 1.61E—17 |
| AKR1C4 | 0 | 0 | NA | NA | AKR1C4 | NA | NA | NA | NA |
| STAR | 109.53 | 64.21 | −0.77 | 1.64E—03 | Star | 168.45 | 118.76 | −0.41 | 2.71E—02 |
| INSL3 | 0 | 0 | NA | NA | Insl3 | 1.86 | 11.42 | 0.12 | 0.27 |
| AR | 35.55 | 15.66 | −1.19 | 5.96E—03 | Ar | 1748.07 | 1578.09 | −0.14 | 0.20 |
| FSHR | 0 | 0 | NA | NA | Fshr | NA | NA | NA | NA |
| CLU | 705.48 | 1397.10 | 0.99 | 1.30E—32 | Clu | 44.01 | 16.50 | −0.51 | 2.48E—02 |
| TGFB1 | 9475.36 | 9462.78 | 0.00 | 0.98 | Tgfb1 | 2093.51 | 1954.46 | −0.10 | 0.21 |
| TFRC | 16835.42 | 12631.42 | −0.41 | 1.82E—45 | Tfrc | 13721.71 | 10185.63 | −0.42 | 3.53E—14 |
| GATA1 | 0 | 0 | NA | NA | Gata1 | NA | NA | NA | NA |
| WT1 | 3038.70 | 1067.08 | −1.51 | 7.16E—118 | Wt1 | 7.3 | 14.94 | 0.12 | 0.42 |
| CYP19A1 | 0 | 0.43 | 1.34 | NA | Cyp19a1 | NA | NA | NA | NA |
| SOX9 | 875.90 | 427.65 | −1.04 | 3.04E—30 | Sox9 | 1299.60 | 499.48 | −1.32 | 1.48E—54 |
base mean from DESeq2 represents the average of normalized count values divided by size factors, calculated across all samples.
log2 fold change indicates the magnitude of change in gene expression between the treatment and control groups. Gene name abbrevations: LHCGR, luteinizing hormone/choriogonadotropin receptor; CYP11A1, cytochrome P450 family 11 subfamily A member 1; HSD3B1, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; CYP17A1, cytochrome P450 family 17 subfamily A member 1; HSD17B3, hydroxysteroid 17-beta dehydrogenase 3; SRD5A1, steroid 5 alpha-reductase 1; AKR1C4, aldo-keto reductase family 1 member C4; STAR, steroidogenic acute regulatory protein; INSL3, insulin like 3; AR, androgen receptor; FSHR, follicle stimulating hormone receptor; CLU, clusterin; TGFB1, transforming growth factor beta 1; TFRC, transferrin receptor; GATA1, GATA binding protein 1; WT1, Wilms tumor 1; CYP19A1, cytochrome P450 family 19 subfamily A member 1; SOX9, SRY-box transcription factor 9.