Table 3.
Comparison of diagnostic efficacy of mp-PI-RADS, bp-PI-RADS and S-PI-RADS at different PSA levels
| Variables | cut-off | SEN, % | SPE, % | ACC, % | PPV, % | NPV, % | F1-score | AUC | P value* |
|---|---|---|---|---|---|---|---|---|---|
| Overall PSA level | |||||||||
| mp-PI-RADS | 4 | 80.1 | 85.4 | 83.1 | 81.1 | 84.7 | 0.806 (0.752–0.860) |
0.889 (0.863–0.914) |
0.285a |
| bp-PI-RADS | 4 | 77.9 | 84.8 | 81.8 | 80.0 | 83.1 | 0.789 (0.734–0.844) |
0.882 (0.856–0.908) |
0.072b |
| S-PI-RADS | 3b | 88.8 | 75.5 | 81.3 | 73.8 | 89.7 | 0.806 (0.752–0.860) |
0.853 (0.824–0.882) |
0.018c |
| PSA ≤ 10 ng/ml | |||||||||
| mp-PI-RADS | 4 | 70.8 | 91.0 | 85.7 | 73.0 | 90.0 | 0.719 (0.642–0.796) |
0.882 (0.836–0.928) |
0.306a |
| bp-PI-RADS | 3 | 93.8 | 64.4 | 71.9 | 47.7 | 96.8 | 0.632 (0.548–0.716) |
0.867 (0.819–0.914) |
0.129b |
| S-PI-RADS | 3b | 80.0 | 75.0 | 76.3 | 52.5 | 91.6 | 0.634 (0.552–0.716) |
0.818 (0.764–0.872) |
0.021c |
| PSA > 10 ng/ml | |||||||||
| mp-PI-RADS | 4 | 83.2 | 78.7 | 81.2 | 83.6 | 78.2 | 0.832 (0.778–0.886) |
0.874 (0.837–0.910) |
1.000a |
| bp-PI-RADS | 4 | 81.2 | 81.3 | 81.2 | 85.0 | 76.8 | 0.831 (0.777–0.885) |
0.872 (0.836–0.909) |
1.000b |
| S-PI-RADS | 3b | 91.6 | 76.1 | 84.9 | 83.3 | 87.4 | 0.873 (0.822–0.924) |
0.866 (0.827–0.904) |
1.000c |
SEN sensitivity, SPE specificity, ACC accuracy, PPV positive predictive value, NPV negative predictive value, AUC areas under the curve
*, The differences in AUCs among the bp-PI-RADS, S-PI-RADS and mp-PI-RADS were compared using the Delong test; a mp-PI-RADS vs. bp-PI-RADS, b bp-PI-RADS vs. S-PI-RADS, c mp-PI-RADS vs. S-PI-RADS. P-values were adjusted using the Bomferroni correction