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. 2025 Aug 25;25:2907. doi: 10.1186/s12889-025-24254-2

Table 3.

Results of analyses examining mediation of the relationships of wave IV weight category with metabolic health (Hypothesis 2 A) and change in BMI (Hypothesis 2B) via self-perceived weight, among eligible participants in the add health study

Hypothesis 2 A:
Association Between Wave IV Weight Category and Wave V Metabolic Health, Mediated by Self-Perceived Weight
(n = 788)
Wave IV Weight Category Direct Effects
Risk Difference (95% CI)
Indirect Effects
Risk Difference
(95% CI)
Total Effects
Risk Difference (95% CI)
Normal weight Ref Ref Ref
Overweight 0.15 (0.060, 0.24) 0.0046 (− 0.025, 0.033) 0.15 (0.071, 0.24)
Obesity 0.31 (0.20, 0.41) 0.0095 (− 0.050, 0.071) 0.32 (0.24, 0.39)
Hypothesis 2B:
Association Between Wave IV Weight Category and change in BMI between Wave IV and Wave V, Mediated by Self-Perceived Weight
(n = 901)
Wave IV Weight Category Direct Effects
β (95% CI)
Indirect Effects
β (95% CI)
Total Effects
β (95% CI)
Normal weight Ref Ref Ref
Overweight 0.76 (− 0.010, 1.51) − 0.30 (− 0.74, 0.14) 0.45 (− 0.18, 1.07)
Obesity − 0.48 (− 1.54, 0.60) − 0.51 (− 1.26, 0.24) − 0.98 (− 1.74, − 0.21)

BMI body mass index, CI confidence interval

Bold indicates statistical significance at the α = 0.05 level

The R mediation package was used to estimate direct, indirect, and total effects. Models were adjusted for Wave IV age, race, sex, Wave IV educational attainment, and Wave IV smoking status