Table 2.

Effect of high fat diet on development of metabolic syndrome and its component in mice

No	Animal	Diet	Duration	Effect	Author
1.	Male C57BL/6J mice	HFD 37%	6 weeks	• Weight gain. • Glucose metabolic disturbance. • Dyslipidemia. • Inflammation.	[165]
2.	Male C57BL/6J mice	HFD 37.1%	20 weeks	• Obesity. • Insulin resistance. • Dyslipidemia. • Fatty liver and liver dysfunction.	[166]
3.	Male C57BL/6J mice	HFD 45%	12 weeks	• Increased body weight. • Hepatic steatosis. • Impaired intestinal barrier integrity.	[167]
4.	Male C57BL/6J mice	HFD 45%	16 weeks	• Glucose metabolic disturbance. • Insulin resistance. • Dyslipidemia. • Imbalance in gut microbiota.	[168]
5.	Male C57BL/6J mice	HFD 60%	8 weeks	• Weight gain. • Glucose intolerance. • Elevated serum lipid level. • Oxidative stress. • Imbalance in gut microbiota.	[169]
6.	Male C57BL/6J mice	HFD 60%	8 weeks	• Weight gain • Dyslipidemia. • Hepatic steatosis. • Gut dysbiosis	[170]
7.	Male C57BL/6 mice	HFD 60%	16 weeks	• Increased mass gain. • Impaired in glucose clearness. • Insulin resistance. • fatty liver	[171]