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. 2025 Aug 25;25:659. doi: 10.1186/s12877-025-06298-6

Table 2.

Effects of Anti-dementia drug use on costs by drug class

Anti-dementia Drugs ChEIs NMDAR Antagonist (Memantine)
Costs Changing ($) 95% CI P value Costs Changing ($) 95% CI P value Costs Changing ($) 95% CI P value
Total Costs −1,612.07 −4,668.72 1,444.59 0.301 −2,385.62 −5,578.66 807.41 0.143 1,644.27 −2,722.50 6,011.04 0.461
Medicare Costs −4,804.26 −6,904.09 −2,704.44 < 0.001 −5,267.62 −7,434.26 −3,100.98 < 0.001 −3,216.34 −6,447.73 15.04 0.051
OOP Costs −36.63 −1,455.29 1,382.04 0.960 −458.08 −1,917.07 1,000.92 0.538 648.58 −1,250.17 2,547.33 0.503
Inpatient Costs −2,842.48 −4,020.36 −1,664.60 < 0.001 −3,044.49 −4,230.54 −1,858.43 < 0.001 −1,993.62 −4,044.24 57.00 0.057
Outpatient Costs 61.59 −597.83 721.02 0.855 −116.40 −696.44 463.64 0.694 253.75 −779.82 1,287.33 0.630

ChEIs Cholinesterase inhibitors, NMDAR N-methyl-D-aspartate receptors, OOP out-of-pocket