Table 4.

Effects of various metabolic indicators in the diagnosis of LOS

Index	Cut-off	AUC (95%CI)	Sensitivity	Specificity	PPV	NPV	Accuracy	P
PCT	0.505	0.918 (0.882, 0.954)	93.8%	91.8%	92.8%	93.0%	0.93	< 0.001
CRP	4.970	0.853 (0.808, 0.898)	78.7%	94.3%	93.9%	79.8%	0.86	< 0.001
Lac	2.495	0.933 (0.901, 0.965)	93.8%	92.5%	93.3%	93.0%	0.92	< 0.001
IL-6	10.030	0.697 (0.639, 0.755)	56.2%	91.8%	88.5%	65.2%	0.73	< 0.001
IL-1β	5.365	0.934 (0.904, 0.963)	91.0%	92.5%	93.1%	90.2%	0.92	< 0.001
IL-12	41.810	0.810 (0.758, 0.862)	79.2%	93.1%	92.8%	79.9%	0.86	< 0.001
CRP + Lac + IL-1β	0.264	0.958 (0.934, 0.983)	97.8%	91.8%	93.0%	97.4%	0.95	< 0.001

Metabolic indicators with AUC > 0.8 were included for screening to obtain indicators for combined diagnosis, and ROC analysis was performed

PCT Procalcitonin, CRP C-reactive Protein, Lac Lactate, PPV Positive Predictive Value, NPV Negative Predictive Value