Table 3.
CpG > TpG and non-CpG C > T mutations on the leading or lagging replication strand in dMutLα and dMutSα colorectal cancers. Median (IQR) shown. PLeadingversusLagging from Wilcoxon signed-rank test. PdMutSα versusdMutLα from Wilcoxon test
| Leading strand mutations | Lagging strand mutations | log2(Leading/Lagging) | PLeadingversusLagging | PdMutSα versusdMutLα | ||
|---|---|---|---|---|---|---|
| CpG > TpG | dMutLα (n = 164) | 3428 (2761–4489) | 2987 (2440–4034) | 0.172 (0.130–0.219) | < 2.2 × 10−16 | 0.37 |
| dMutSα (n = 20) | 6704 (5412–9067) | 5959 (4935–7853) | 0.184 (0.140–0.225) | 1.9 × 10−6 | ||
| Non-CpG C > T | dMutLα (n = 164) | 5827 (4785–7822) | 4909 (4078–6249) | 0.260 (0.197–0.317) | < 2.2 × 10−16 | 0.0035 |
| dMutSα (n = 20) | 7331 (5908–9617) | 5729 (4835–7891) | 0.303 (0.278–0.395) | 1.9 × 10−6 | ||
| All SBS mutations | dMutLα (n = 164) | 22,723 (18,386–27,739) | 24,992 (20,237–31,192) | − 0.135 (− 0.177 to − 0.103) | < 2.2 × 10−16 | 2.8 × 10−5 |
| dMutSα (n = 20) | 28,424 (21,530–34,515) | 30,638 (22,400–36,580) | − 0.048 (− 0.094 to − 0.015) | 8.5 × 10−4 |