Table 2.
Multivariable model assessing risk factors of VTE, all-cause death and bleeding events in the oldest-old COVID-19 patients. Results expressed as hazard ratios (95% confidence intervals)
| VTE | Death | Bleeding | |
|---|---|---|---|
| Male gender | – | – | 2.04 (1.30, 3.32)† |
| Cardiovascular disease | – | 1.50 (1.17, 1.93) ‡ | – |
| Gastrointestinal Disease | 1.71 (1.00, 2.92) | – | – |
| Stroke | – | 1.37 (1.10, 1.71)† | 1.59 (1.03, 2.40)* |
| VTE history | 3.34 (1.59, 6.98)‡ | – | – |
| Disease severity at admission | |||
| moderate | Reference | Reference | Reference |
| severe | 1.83 (1.20, 2.79)† | 3.13(2.43, 4.02) ‡ | 1.54(0.97, 2.45) |
| critical | 1.99(1.12, 3.55)* | 8.06(6.09, 10.66) ‡ | 3.21(1.90, 5.40) ‡ |
| PLT 100–300 (*109/L) | Reference | Reference | Reference |
| ≥ 300 | 1.95(1.13, 3.36)* | 0.71(0.47, 1.07) | – |
| < 100 | 0.86(0.43, 1.73) | 1.40(1.03, 1.90)* | – |
| HGB ≥ 120 (g/L) | Reference | Reference | Reference |
| 90–120 | 1.14(0.76, 1.72) | – | 1.03 (0.65, 1.61) |
| < 90 | 1.93 (1.03, 3.62)* | – | 2.92 (1.60, 5.22)‡ |
| D-dimer < 2 (mg/L) | Reference | Reference | Reference |
| ≥ 2 | 2.97 (1.30, 6.83)* | 3.22 (1.94, 5.33) ‡ | – |
| eGFR ≥ 90 (mL/min/1.73m2) | Reference | Reference | Reference |
| 60–89 | – | 1.45 (0.93, 2.27) | – |
| 30–59 | – | 1.75 (1.10, 2.79)* | – |
| < 30 | – | 3.09 (1.90, 5.04) ‡ | – |
| Prophylaxis | 0.50 (0.33, 0.75) ‡ | 0.80 (0.65, 0.99)* | 0.90 (0.60, 1.34) |
| Antiviral drugs | 1.78 (1.13, 2.80)* | – | – |
Abbreviation: VTE, venous thromboembolism; PLT, platelet; HGB, hemoglobin; eGFR, estimated glomerular filtration rate
*P < 0.05; †P < 0.01; ‡P < 0.001