Title {1}	Implementation of Metformin Therapy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD): study protocol for a phase III, multi-centre, randomized, placebo-controlled trial evaluating the long-term efficacy of metformin in slowing the rate of kidney function decline in patients with autosomal dominant polycystic kidney disease
Trial registration {2a and 2b}	ClinicalTrials.gov identifier NCT04939935
Protocol version {3}	Version 3.2, April 2024
Funding {4}	1. Medical Research Future Fund (MRFF), Grant MRF1199853 2. National Health and Medical Research Council (NHMRC) • Better Evidence And Translation in Chronic Kidney Disease (BEAT-CKD), Grant APP1092957 3. PKD Australia (2018) 4. Otsuka Australia Pharmaceutical Pty Ltd (2018) 5. Efficacy and Mechanism Evaluation (EME) Programme (an Medical Research Council (MRC) and National Institute for Health and Care Research (NIHR) partnership), Grant NIHR156614 6. Health Research Council of New Zealand, Grant 23/093/A 7. Indian Council of Medical Research, Grant IIRP-2023–4050
Author details {5a}	1. Princess Alexandra Hospital, Metro South Hospital and Health Service, Brisbane, Australia 2. The University of Queensland, Brisbane, Australia 3. Sheffield Kidney Institute, Sheffield, United Kingdom 4. George Institute for Global Health India, New Delhi, India 5. University of Otago, Dunedin, New Zealand 6. University of Bari Aldo Moro, Bari, Italy 7. Townsville University Hospital, Townsville Hospital and Health Service, Townsville, Australia 8. College of Medicine and Dentistry, James Cook University, Townsville, Australia
Name and contact information for the trial sponsor {5b}	The University of Queensland (UQ) acting through the Australasian Kidney Trials Network (AKTN). The trial sponsor can be contacted at aktn@uq.edu.au or on + 61 7 3443 7881
Role of sponsor {5c}	The Australasian Kidney Trials Network will be the Central Coordinating Centre and will be responsible for convening and reporting to the Global Steering Committee (GSC). The GSC will be responsible for the oversight of the study. AKTN will also be responsible for developing and maintaining charters for the GSC and Data and Safety Monitoring Board (DSMB)