Table 4.
Results of Logistic Regression Models for Treatment Response and Adverse Cognitive Effects With ECT
| Variable name | Treatment response adjusted odds ratio (95% CI)a,b |
Adverse cognitive effects adjusted odds ratio (95% CI)a,c |
|---|---|---|
| Presence of psychotic depression | 1.04 (0.95–1.15) | 1.30 (0.78–2.18) |
| Age (y) | 1.00 (1.00–1.01) | 1.00 (0.98–1.01) |
| Female sex | 1.02 (0.95–1.10) | 0.83 (0.54–1.26) |
| Voluntary | 0.92 (0.82–1.03) | 1.53 (0.81–2.90) |
| Incapable to consent | 1.00 (0.84–1.18) | 0.88 (0.37–2.07) |
| Catatonia | 1.30 (0.99–1.71) | 0.92 (0.18–4.88) |
| Less severe baseline symptoms (CGI-S of 3 or 4) d | 0.93 (0.84–1.04) | 1.28 (0.66–2.48) |
| More severe baseline symptoms (CGI-S of 6 or 7) d | 1.05 (0.96–1.13) | 1.32 (0.84–2.10) |
| Antidepressants | 1.10 (1.01–1.20) | 0.63 (0.40–1.00) |
| Antipsychotics | 1.03 (0.95–1.11) | 1.07 (0.69–1.66) |
| Benzodiazepines | 0.95 (0.88–1.04) | 1.03 (0.64–1.65) |
| Suicidality | 1.01 (0.93–1.10) | 1.61 (1.02–2.55) |
| Failed pharmacotherapy | 0.94 (0.86–1.03) | 1.74 (1.05–2.89) |
| Prior response to ECT | 1.08 (0.98–1.18) | 0.93 (0.55–1.56) |
| Patient preference | 0.92 (0.85–1.01) | 0.99 (0.58–1.69) |
| Noncompliance to medications | 0.86 (0.69–1.06) | 0.59 (0.12–2.91) |
| Intolerance to medications | 0.98 (0.85–1.13) | 1.20 (0.53–2.74) |
| RUL starting electrode position e | 1.01 (0.92–1.11) | 0.93 (0.58–1.49) |
a
Statistically significant results are bolded.
b
Model fit was adequate (Hosmer-Lemeshow test P > .05), and c statistic was 0.67.
c
Model fit was adequate (Hosmer-Lemeshow test P > .05), and c statistic was 0.62.
d
Reference group is CGI-S of 5.
e
Reference group is bitemporal electrode position.
Abbreviations: CGI-S = Clinical Global Impression Severity, ECT = electroconvulsive therapy, RUL = right unilateral.