Table 8. In silico toxicity properties for synthesized compounds as calculated by ‘ADMETlab 2.0’ (https://admetmesh.scbdd.com/).

Compounds	hERG	H-HT	DILI	AMES toxicity	Rat oral acute toxicity	FDAMDD	Skin sensitization	Carcinogenicity	Eye corrosion	Eye irritation	Respiratory toxicity
4a	0.055	0.881	0.979	0.998	0.076	0.526	0.52	0.971	0.133	0.97	0.899
4b	0.011	0.832	0.978	0.99	0.15	0.499	0.254	0.955	0.028	0.946	0.922
4c	0.008	0.889	0.976	0.993	0.117	0.262	0.283	0.96	0.081	0.967	0.914
4d	0.016	0.926	0.976	0.993	0.132	0.417	0.289	0.97	0.04	0.958	0.912
4e	0.012	0.885	0.979	0.994	0.127	0.701	0.243	0.97	0.016	0.962	0.874
4f	0.007	0.905	0.971	0.984	0.175	0.383	0.159	0.941	0.032	0.917	0.95
4g	0.026	0.982	0.984	0.988	0.521	0.665	0.132	0.97	0.004	0.294	0.916
4h	0.011	0.65	0.977	0.98	0.105	0.457	0.328	0.957	0.199	0.973	0.936
4i	0.006	0.881	0.976	0.993	0.258	0.298	0.337	0.959	0.136	0.974	0.933
4j	0.013	0.711	0.977	0.986	0.055	0.668	0.25	0.955	0.025	0.916	0.947
4k	0.007	0.857	0.977	0.989	0.165	0.303	0.292	0.962	0.063	0.966	0.932
4l	0.03	0.952	0.978	0.993	0.273	0.762	0.323	0.967	0.036	0.955	0.94
4m	0.009	0.85	0.975	0.988	0.122	0.664	0.28	0.954	0.056	0.934	0.921
4n	0.008	0.865	0.974	0.987	0.182	0.568	0.323	0.962	0.088	0.959	0.934