Table 1.

Key signaling pathways and associated DEPs from aged male subjects.

Signaling pathways	Associated proteins	Accession number	Brain injury induced modulation	Fold change
Mitochondrial Dysfunction	ATP synthase subunit g, mitochondrial	Q9CPQ8	↓	0.71
	Aconitate hydratase, mitochondrial	Q99KI0	↓	0.79
	Cytochrome c, somatic	P62897	↓	0.83
	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	Q8BMF4	↓	0.69
	Dihydrolipoyl dehydrogenase, mitochondrial	O08749	↓	0.54
	3-hydroxyacyl-CoA dehydrogenase type-2	O08756	↓	0.78
	Isocitrate dehydrogenase [NADP], mitochondrial	P54071	↓	0.50
	Superoxide dismutase 1	P08228	↓	0.62
	Superoxide dismutase mitochondrial	P09671	↓	0.71
Intrinsic Pathway for Apoptosis	Cytochrome c	P62897	↓	0.83
	Calcineurin subunit B type 1	Q63810	↑	1.72
	14–3-3 protein beta/alpha	Q9CQV8	↓	0.61
	14–3-3 protein epsilon	P62259	↓	0.72
	14–3-3 protein gamma	P61982	↓	0.72
	14–3-3 protein eta	P68510	↓	0.56
	14–3-3 protein theta	P68254	↓	0.67
Response to elevated platelet cytosolic Ca2+	Alpha-actinin-1	Q7TPR4	↑	1.52
	Albumin	P07724	↑	7.23
	Endoplasmic reticulum chaperone BiP	P20029	↓	0.80
	Peptidyl-prolyl cis-trans isomerase A	P17742	↓	0.89
	Fibrinogen beta chain	Q8K0E8	↑	42.70
	Fibrinogen alpha chain	E9PV24	↑	10.89
	Fibrinogen gamma chain	Q8VCM7	↑	42.29
	Superoxide dismutase [Cu─Zn]	P08228	↓	0.62
Regulation of TLR by endogenous ligand	Fibrinogen alpha chain	E9PV24	↑	10.89
	Fibrinogen beta chain	Q8K0E8	↑	42.70
	Fibrinogen gamma chain	Q8VCM7	↑	42.29
	Protein S100-A9	P31725	↑	59.24
14–3-3-mediated Signaling	Glial fibrillary acidic protein	P03995	↑	2.22
	14–3-3 protein beta/alpha	Q9CQV8	↓	0.61
	14–3-3 protein epsilon	P62259	↓	0.72
	14–3-3 protein gamma	P61982	↓	0.72
	14–3-3 protein eta	P68510	↓	0.56
	14–3-3 protein theta	P68254	↓	0.67
Neuroinflammation Signaling Pathway	Calbindin	P12658	↓	0.53
	Calretinin	Q08331	↓	0.43
	Glutamate decarboxylase 2	P48320	↓	0.15
	Glutamine synthetase	P15105	↓	0.80
	Calcineurin subunit B type 1	Q63810	↑	1.72
	Superoxide dismutase [Mn]	P09671	↓	0.71
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	Protein S100-A9	P31725	↑	59.24