Table 2.
Key signaling pathways and associated DEPs from aged female subjects.
| Signaling pathways | Associated proteins | Accession number |
Brain injury-induced modulation |
Fold change |
|---|---|---|---|---|
| Mitochondrial Dysfunction | Sodium/potassium-transporting ATPase subunit beta-1 | P14094 | ↓ | 0.73 |
| ATP synthase subunit gamma, mitochondrial | Q91VR2 | ↓ | 0.68 | |
| ATP synthase F(0) complex subunit B1, mitochondrial | Q9CQQ7 | ↓ | 0.56 | |
| Calcium/calmodulin-dependent protein kinase type II subunit alpha | P11798 | ↓ | 0.77 | |
| Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | P19783 | ↓ | 0.58 | |
| Cytochrome c oxidase subunit 6C | Q9CPQ1 | ↓ | 0.39 | |
| Cytochrome c, somatic | P62897 | ↑ | 1.57 | |
| Dynamin-1-like protein | Q8K1M6 | ↓ | 0.51 | |
| Glycerol-3-phosphate dehydrogenase, mitochondrial | Q64521 | ↓ | 0.24 | |
| Glutathione peroxidase 1 | P11352 | ↑ | 11.68 | |
| Maleylacetoacetate isomerase | Q9WVL0 | ↑ | 83.65 | |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | Q99LC3 | ↓ | 0.61 | |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 | Q9D8B4 | ↓ | 0.31 | |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | Q9CPP6 | ↓ | 0.30 | |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | Q9DC69 | ↓ | 0.40 | |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | Q9CQJ8 | ↓ | 0.15 | |
| NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | Q91VD9 | ↓ | 0.67 | |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | P52503 | ↓ | 0.58 | |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | Q9DC70 | ↓ | 0.30 | |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | Q8K3J1 | ↓ | 0.34 | |
| NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Q91YT0 | ↓ | 0.53 | |
| NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | Q9D6J6 | ↓ | 0.35 | |
| 2-oxoglutarate dehydrogenase, mitochondrial | Q60597 | ↓ | 0.69 | |
| Dynamin-like 120 kDa protein, mitochondrial | P58281 | ↓ | 0.36 | |
| cAMP-dependent protein kinase catalytic subunit beta | P68181 | ↓ | 0.11 | |
| Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | Q8K2B3 | ↓ | 0.61 | |
| Cytochrome b-c1 complex subunit 7 | Q9D855 | ↓ | 0.15 | |
| Cytochrome b-c1 complex subunit 1, mitochondrial | Q9CZ13 | ↓ | 0.72 | |
| Cytochrome b-c1 complex subunit 2, mitochondrial | Q9DB77 | ↓ | 0.59 | |
| Cytochrome b-c1 complex subunit 8 | Q9CQ69 | ↓ | 0.61 | |
| Voltage-dependent anion-selective channel protein 1 | Q60932 | ↓ | 0.56 | |
| Voltage-dependent anion-selective channel protein 2 | Q60930 | ↓ | 0.55 | |
| Voltage-dependent anion-selective channel protein 3 | Q60931 | ↓ | 0.48 | |
| Sirtuin Signaling Pathway | ATP synthase subunit gamma, mitochondrial | Q91VR2 | ↓ | 0.68 |
| ATP synthase F(0) complex subunit B1, mitochondrial | Q9CQQ7 | ↓ | 0.56 | |
| Histone H1.2 | P15864 | ↑ | 11.34 | |
| Histone H1.4 | P43274 | ↑ | 4.33 | |
| L-lactate dehydrogenase A chain | P06151 | ↓ | 0.81 | |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | Q99LC3 | ↓ | 0.61 | |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 | Q9D8B4 | ↓ | 0.31 | |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | Q9CPP6 | ↓ | 0.30 | |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | Q9DC69 | ↓ | 0.40 | |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | Q9CQJ8 | ↓ | 0.15 | |
| NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | Q91VD9 | ↓ | 0.67 | |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | P52503 | ↓ | 0.58 | |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | Q9DC70 | ↓ | 0.30 | |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | Q8K3J1 | ↓ | 0.34 | |
| NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Q91YT0 | ↓ | 0.53 | |
| NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | Q9D6J6 | ↓ | 0.35 | |
| ATP-dependent 6-phosphofructokinase, muscle type | P47857 | ↓ | 0.68 | |
| Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | Q8K2B3 | ↓ | 0.61 | |
| ADP/ATP translocase 1 | P48962 | ↓ | 0.45 | |
| ADP/ATP translocase 2 | P51881 | ↓ | 0.49 | |
| Solute carrier family 2, facilitated glucose transporter member 1 | P17809 | ↓ | 0.15 | |
| Tubulin alpha-4A chain | P68368 | ↓ | 0.79 | |
| Cytochrome b-c1 complex subunit 2, mitochondrial | Q9DB77 | ↓ | 0.59 | |
| Voltage-dependent anion-selective channel protein 1 | Q60932 | ↓ | 0.56 | |
| Voltage-dependent anion-selective channel protein 2 | Q60930 | ↓ | 0.55 | |
| Voltage-dependent anion-selective channel protein 3 | Q60931 | ↓ | 0.48 | |
| Neutrophil Extracellular Trap Signaling Pathway | ATP synthase subunit gamma, mitochondrial | Q91VR2 | ↓ | 0.68 |
| ATP synthase F(0) complex subunit B1, mitochondrial | Q9CQQ7 | ↓ | 0.56 | |
| Ig gamma-2B chain C region | P01867 | ↑ | 107.85 | |
| Immunoglobulin heavy constant mu | P01872 | ↑ | 1062.05 | |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | Q99LC3 | ↓ | 0.61 | |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 | Q9D8B4 | ↓ | 0.31 | |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | Q9CPP6 | ↓ | 0.30 | |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | Q9DC69 | ↓ | 0.40 | |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | Q9CQJ8 | ↓ | 0.15 | |
| NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | Q91VD9 | ↓ | 0.67 | |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | P52503 | ↓ | 0.58 | |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | Q9DC70 | ↓ | 0.30 | |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | Q8K3J1 | ↓ | 0.34 | |
| NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Q91YT0 | ↓ | 0.53 | |
| NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | Q9D6J6 | ↓ | 0.35 | |
| Protein disulfide-isomerase A3 | P27773 | ↑ | 1.38 | |
| Ras-related C3 botulinum toxin substrate 1 | P63001 | ↓ | 0.59 | |
| Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | Q8K2B3 | ↓ | 0.61 | |
| ADP/ATP translocase 1 | P48962 | ↓ | 0.45 | |
| ADP/ATP translocase 2 | P51881 | ↓ | 0.49 | |
| Solute carrier family 2, facilitated glucose transporter member 1 | P17809 | ↓ | 0.15 | |
| Toll-like receptor 7 | P58681 | ↑ | 83.97 | |
| Cytochrome b-c1 complex subunit 2, mitochondrial | Q9DB77 | ↓ | 0.59 | |
| Voltage-dependent anion-selective channel protein 1 | Q60932 | ↓ | 0.56 | |
| Voltage-dependent anion-selective channel protein 2 | Q60930 | ↓ | 0.55 | |
| Voltage-dependent anion-selective channel protein 3 | Q60931 | ↓ | 0.48 | |
| Clathrin-mediated Endocytosis Signaling | Albumin | P07724 | ↑ | 13.54 |
| Amphiphysin | Q7TQF7 | ↓ | 0.63 | |
| AP-2 complex subunit alpha-1 | P17426 | ↓ | 0.73 | |
| AP-2 complex subunit alpha-2 | P17427 | ↓ | 0.56 | |
| AP-2 complex subunit mu | P84091 | ↓ | 0.56 | |
| Actin-related protein 2/3 complex subunit 1A | Q9R0Q6 | ↓ | 0.55 | |
| Clathrin heavy chain 1 | Q68FD5 | ↓ | 0.72 | |
| Clusterin | Q06890 | ↑ | 1.39 | |
| Dynamin-1 | P39053 | ↓ | 0.79 | |
| Protein kinase C and casein kinase substrate in neurons protein 1 | Q61644 | ↓ | 0.72 | |
| Vesicle-associated membrane protein 2 | P63044 | ↓ | 0.60 | |
| Endophilin-A1 | Q62420 | ↓ | 0.72 | |
| Synaptojanin-1 | Q8CHC4 | ↓ | 0.57 | |
| Serotransferrin | Q921I1 | ↑ | 11.48 | |
| Glucose metabolism | Aspartate aminotransferase, cytoplasmic | P05201 | ↑ | 1.14 |
| Glucose-6-phosphate isomerase | P06745 | ↓ | 0.75 | |
| Hexokinase-1 | P17710 | ↓ | 0.70 | |
| ATP-dependent 6-phosphofructokinase, liver type | P12382 | ↓ | 0.62 | |
| ATP-dependent 6-phosphofructokinase, muscle type | P47857 | ↓ | 0.68 | |
| Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha | Q76MZ3 | ↓ | 0.63 | |
| Mitochondrial 2-oxoglutarate/malate carrier protein | Q9CR62 | ↓ | 0.46 | |
| Calcium-binding mitochondrial carrier protein Aralar1 | Q8BH59 | ↓ | 0.55 | |
| Calcium-binding mitochondrial carrier protein Aralar2 | Q9QXX4 | ↓ | 0.41 | |
| Ferroptosis Signaling Pathway | Ferritin light chain 1 | P29391 | ↑ | 4.09 |
| Glutaminase liver isoform, mitochondrial | Q571F8 | ↓ | 0.29 | |
| Histone H2A type 2-C | Q64523 | ↑ | 2.15 | |
| Histone H2A type 2-B | Q64522 | ↑ | 1.97 | |
| Histone H2A.Z | P0C0S6 | ↑ | 2.47 | |
| Core histone macro-H2A.1 | Q9QZQ8 | ↑ | 2.50 | |
| Ras-related protein Rap-1A | P62835 | ↓ | 0.39 | |
| 4F2 cell-surface antigen heavy chain | P10852 | ↓ | 0.67 | |
| Serotransferrin | Q921I1 | ↑ | 11.48 | |
| Voltage-dependent anion-selective channel protein 2 | Q60930 | ↓ | 0.55 | |
| 14–3-3-mediated Signaling | Glial fibrillary acidic protein | P03995 | ↑ | 2.04 |
| Protein disulfide-isomerase A3 | P27773 | ↑ | 1.38 | |
| Ras-related protein Rap-1A | P62835 | ↓ | 0.39 | |
| Tubulin alpha-4A chain | P68368 | ↓ | 0.79 | |
| Vimentin | P20152 | ↑ | 3.03 | |
| 14–3-3 protein beta/alpha | Q9CQV8 | ↓ | 0.59 | |
| 14–3-3 protein epsilon | P62259 | ↓ | 0.71 | |
| 14–3-3 protein gamma | P61982 | ↓ | 0.68 | |
| 14–3-3 protein eta | P68510 | ↓ | 0.56 | |
| 14–3-3 protein theta | P68254 | ↓ | 0.65 | |
| 14–3-3 protein zeta/delta | P63101 | ↓ | 0.81 |