Table 1. Physicochemical properties of the synthesized compounds^a.

Compound	Mi Log P	TPSA	n-atoms	M.W.	nON	nOHNH	n-violations	n-rotb	Volume
1	1.96	115.72	28	378.38	7	4	0	3	325.43
2	2.74	141.72	32	438.44	9	4	0	7	307.00
6	4.49	98.36	34	458.51	7	1	0	1	405.63

^aAbbreviations: Mi log P, logarithm of partition coefficient of compound between n-octanol and water; MV, molecular volume; MW, molecular weight; n atoms, number of atoms; n-ON acceptors, number of hydrogen bond acceptors; n-OHNH donors, number of hydrogen bonds donors; n rotb, number ofroutable bonds; n violations, number of violations; TPSA, topological polar surface area.