TABLE 2.

Distribution of international Working Group (IWG) responses for MDS/MPN patients

IWG MDS-MPN 2015 Response	N (%)/Median [range]
Objective Responses a	20/35 (57)
CI Spleen (spleen > 5 cm)	9/14 (64)
After AZA addition	5/9 (56)
Median time to CI spleen, (month)	1.8 (0.7–7.3)
After AZA addition	0.8 (0.3–4.5)
CI Total symptom Score (TSS > 20)	14/18 (78)
Median time to CI TSS, (month)	1 (0.9–1.8)
CI Transfusion Independence	1/11 (9)
Time to transfusion independence	3.7 months
Marrow response
Partial marrow response	9/22 (41)
Optimal marrow response	1/22 (5)
Median time to marrow response, (month)	5.5 (2–11.2)
BM blast reduction (>5% blast)	7/10 (70)
Complete cytogenetic remission	1/5 (20)
Time to cytogenetic remission	32.1 months

^a(11 patients have >1 response).

Data are expressed as n (%) or median [range].

Abbreviations; CI: clinical improvement; AZA: azacytidine; TSS: total symptom score; BM: Bone marrow.