TABLE 3.

Adverse events on study, regardless of causality

Toxicities	Grade 1–2 N (%)	Grade 3–4 N (%)
Constipation	8 (23)
Nausea/Vomiting	8 (23)
Diarrhea	3 (9)
Myalgias/Abdominal Pain	3 (9)
Chest pain	2 (6)	1 (3)
Anorexia	2 (6)
Dizziness	2 (6)
Fatigue	1 (3)	2 (6)
Bruising	2 (6)
Insomnia	1 (3)
Edema - limbs	1 (3)	1 (3)
Periorbital edema	1 (3)	1 (3)
Shingles	1 (3)
Actinic Keratosis	2 (6)
Urinary tract infections	2 (6)	3 (9)
Pneumonia	2 (6)	3 (9)
Skin/soft tissue infections	2 (6)	3 (9)
Constrictive pericarditis		1 (3)
Heart failure	1 (3)	3 (9)
Headache	1 (3)
Hyperuricemia	1 (3)
Transaminitis	7 (20)
Hyperbilirubinemia	2 (6)
Thrombocytopenia	7 (20)	19 (54)
Anemia	6 (17)	18 (51)
Neutropenia	1 (3)	10 (29)