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. Author manuscript; available in PMC: 2025 Aug 25.
Published in final edited form as: Int J Drug Policy. 2024 May 9;141:104397. doi: 10.1016/j.drugpo.2024.104397

Table 3.

Most common polysubstance combinations involved in drug-related deaths, 2021.

Jurisdiction Population per square mile, 2020 US Census n Most Common Second Most Common Third Most Common

States
Alaska 1.3 228 Methamphetamine, Fentanyl, Heroin (N=23) Methamphetamine, Fentanyl (N=20) Rx Opioids, Methamphetamine, Fentanyl (N=18)
Connecticut 744.7 1,519 Fentanyl, Cocaine (N=149) Fentanyl, Alcohol (N=92) Fentanyl, Cocaine, Alcohol (N=91)
North Carolina 71.7 1,383 Fentanyl, Cocaine (N=347) Methamphetamine, Fentanyl (N=219) Fentanyl, Cocaine, Alcohol (N=132)
Minnesota 214.7 2,589 Methamphetamine, Fentanyl (N=154) Fentanyl, Alcohol (N=53) Fentanyl, Cocaine (N=49)
Wyoming 5.9 188 Methamphetamine, Fentanyl (N=12) Fentanyl, Heroin (N=10) Methamphetamine, Alcohol (N=10)
Counties
Cobb, GA 2,254.8 168 Fentanyl, Cocaine (N=13) Methamphetamine, Fentanyl (N=11) Fentanyl, Alcohol (N=8)
Cook, IL 5,583.0 2,126 Fentanyl, Cocaine (N=230) Fentanyl, Heroin (N=146) Fentanyl, Alcohol (N=110)
Los Angeles, CA 2,466.9 2,766 Methamphetamine, Fentanyl (N=511) Fentanyl, Cocaine (N=123) Fentanyl, Alcohol (N=81)
Pinal, AZ 79.3 145 Methamphetamine, Fentanyl (N=20) Rx Opioids, Fentanyl (N=5) Fentanyl, Cocaine (N=5)
Sacramento, CA 1,642.1 397 Methamphetamine, Fentanyl (N=29) Fentanyl, Alcohol (N=11) Rx Opioids, Methamphetamine (N=10)
Summit, OH 1,309.2 218 Methamphetamine, Fentanyl (N=50) Fentanyl, Cocaine (N=20) Fentanyl, Alcohol (N=13)
Tarrant, TX 2,439.2 493 Fentanyl, Cocaine (N=30) Methamphetamine, Fentanyl (N=19) Fentanyl, Alcohol (N=14)
Travis, TX 1,297.9 214 Methamphetamine, Cocaine (N=7) Fentanyl, Rx Benzos (N=6) Cocaine, Alcohol (N=6)