TABLE 1 ∣.

Endotype descriptions.

CMVD endotypes	Pathophysiology	Diagnostic cut off	Technique
Adenosine testing
Endothelial independent CMD	Impaired vasodilation endothelial independent dysfunction	CFR < 2.5 HMR > 2.5 IMR > 25 MRR < 2.7	Doppler/thermodilution doppler thermodilution thermodilution
Acetylcholine testing
Endothelial dependent CMD	Impaired vasodilation endothelial dependent dysfunction	<50% ΔCBF Δ coronary diameter (%)	Doppler doppler/thermodilution
Microvascular vasospastic angina (MVA)	Abnormal microvascular vasoconstriction	<90% coronary constriction, Ischemic ECG, Angina	Doppler/thermodilution
Epicardial vasospastic angina (VSA)	Abnormal epicardial vasoconstriction	>90% coronary vasospasm, ischemic ECG, angina	Doppler/thermodilution