Fig. 4. Systemic toxicity evaluation in rats following implantation of Zn and Zn-0.8Mg-0.2Sr rods into the tibial metaphysis for 28 days. (A) The surgical procedure of material implantation (a–d), the condition of wound healing (e), and re-exposure of the surgical site 28 days after surgery (f); (B) hematoxylin and Eosin (H&E) staining of rat heart, liver, spleen, lung, and kidney tissues from the sham, pure Zn, and Zn-0.8Mg 0.2Sr groups; (C) the ion concentrations of Zn²⁺, Mg²⁺, and Sr²⁺ in the blood of rats 28 days after material implantation (n = 4).