Table 1 |.
Overview of the properties of different BMs
| Location | Species | Modulus | Dimensions | Componentsa | Notes | Refs. |
|---|---|---|---|---|---|---|
| Retinal BM (epithelial) | Mouse | 3–4 MPa | Thickness: 75 nm | Vitronectin | 17 | |
| Vascular BM | Macaque | Pores: 45–60 nm Fibers: 25–30 nm Thickness: 100–300 nm |
Thrombospondin Osteonectin α4/α5 laminin | Reflects non-aorta vessels | 17,169 | |
| Aortic BM | Macaque | Pores: 55–65 nm Fibers: 30 nm Thickness: 500 nm |
Thrombospondin Osteonectin α4/α5 laminin | 17,169 | ||
| Descemet’s (epithelial) | Human | 50 kPa | Pores: 60–120 nm Fibers: 30–60 nm Thickness: 130 nm |
Collagen VIII | BM between corneal stroma and endothelial layer | 17,170 |
| Internal limiting membrane | Human | 1.5–5 MPa | Pores: 10–25 nm Fibers: 70–400 nm Thickness: 0.4–10 μm |
BM between retina and vitreous body | 17 | |
| Retinal BM (epithelial) | Human | Thickness: 300 nm | Vitronectin | 17 | ||
| Glomerular BM (endothelial) | Rat | 2–5 kPa | Pores: 10–20 nm Fibers: 5–10 nm Thickness: 50–100 nm |
17 |
a
All BM contains high levels (>50%) of collagen IV as well as perlecan, nidogen, laminin and fibronectin: the highlighted components distinguish the relevant BM from other types.