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Schematic model of the mechanism by which PRRSV Nsp5 inhibits the cGAS-STING signaling pathway, created in MedPeer. The interaction between PRRSV Nsp5 and STING hinders the transport of STING from ER to Golgi apparatus, and thus disrupts the assembly of the STING/TBK1/IKKε/IRF3 signaling complex and downstream antiviral IFN response.
