Table 1. Binding energy score of the docked most active cytotoxic compounds on VEGFR-2.

Compound	Binding score ΔG (kcal mol−1)	Amino acids involved in interaction
Sorafenib	−10.16	Asp1046, Glu885, Cys919, Phe1047, Leu840 and Leu1035
6b	−7.68	Asp1046, Glu885, Leu889, Cys1045 and Phe1047
7b	−7.33	Glu885, Cys1024, Leu889, Ile888, and His1026
8b	−9.13	Asp1046, Glu885, Cys919, Cys1045, Leu840 and Lys868
12a	−8.99	Asp1046, Glu885, Cys1045, Leu889, Ile888, Cys1024 and Arg1027
12b	−8.84	Asp1046, Glu885, Cys1045, Leu889 and Ile888
12c	−8.13	Asp1046, Glu885, Ile888, Cys1024, Ile1025 and Arg1027
13b	−7.89	Asp1046, Leu889, Ile888, Glu815, His816 and Lys868