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. 2025 Jun 16;16(8):e00873. doi: 10.14309/ctg.0000000000000873

Table 2.

Association of LHR, MHR, NHR, and LHR with the prevalence of MASLD in US adults

Crude model OR (95% CI) P value Model 1 OR (95% CI) P value Model 2 OR (95% CI) P value
Log2(LHR) 2.504 (2.266–2.766) <0.0001 2.953 (2.639–3.305) <0.0001 1.853 (1.633–2.103) <0.0001
LHR quartile
 Q1 Ref. Ref. Ref.
 Q2 1.791 (1.452–2.209) <0.0001 2.039 (1.639–2.536) <0.0001 1.429 (1.147–1.780) 0.0049
 Q3 3.332 (2.766–4.014) <0.0001 4.132 (3.328–5.129) <0.0001 2.238 (1.761–2.843) <0.0001
 Q4 4.879 (4.043–5.886) <0.0001 6.648 (5.424–8.148) <0.0001 3.015 (2.380–3.819) <0.0001
P for trend <0.0001 <0.0001 <0.0001
 Log2(MHR) 2.728 (2.519–2.954) <0.0001 2.828 (2.572–3.108) <0.0001 1.685 (1.494–1.901) <0.0001
MHR quartile
 Q1 Ref. Ref. Ref.
 Q2 2.201 (1.904–2.544) <0.0001 2.311 (2.002–2.668) <0.0001 1.479 (1.233–1.774) 0.0005
 Q3 3.402 (2.839–4.076) <0.0001 3.506 (2.892–4.250) <0.0001 1.757 (1.393–2.216) 0.0001
 Q4 5.623 (4.716–6.704) <0.0001 5.876 (4.866–7.095) <0.0001 2.397 (1.930–2.978) <0.0001
P for trend <0.0001 <0.0001 <0.0001
 Log2(NHR) 2.551 (2.313–2.813) <0.0001 2.618 (2.321–2.953) <0.0001 1.470 (1.266–1.707) 0.0001
NHR quartile
 Q1 Ref. Ref. Ref.
 Q2 1.673 (1.335–2.095) 0.0001 1.681 (1.312–2.155) 0.0003 1.121 (0.872–1.439) 0.3841
 Q3 3.074 (2.624–3.600) <0.0001 3.181 (2.689–3.762) <0.0001 1.483 (1.260–1.747) 0.0001
 Q4 5.800 (4.651–7.233) <0.0001 6.009 (4.601–7.846) <0.0001 2.060 (1.484–2.859) 0.0004
P for trend <0.0001 <0.0001 <0.0001
 Log2(PHR) 3.073 (2.795–3.378) <0.0001 3.678 (3.264–4.144) <0.0001 1.879 (1.592–2.218) <0.0001
PHR quartile
 Q1 Ref. Ref. Ref.
 Q2 1.672 (1.337–2.092) 0.0001 1.840 (1.481–2.287) <0.0001 1.322 (1.012–1.728) 0.0545
 Q3 3.156 (2.564–3.886) <0.0001 3.694 (2.965–4.603) <0.0001 2.028 (1.600–2.569) <0.0001
 Q4 5.087 (4.403–5.877) <0.0001 6.503 (5.530–7.647) <0.0001 2.602 (2.075–3.263) <0.0001
P for trend <0.0001 <0.0001 <0.0001

The crude model was not adjusted for any covariates. Model 1 was partially adjusted for age, sex, race/ethnicity, education level, poverty income ratio (PIR), and marital status, whereas Model 2 additionally adjusted for smoking, physical activity, dietary energy intake, diabetes, hypertension, and BMI in addition to Model 1.

CI, confidence interval; LHR, lipoprotein-cholesterol ratio; MASLD, metabolic dysfunction-associated steatotic liver disease; MHR, monocyte-HDL-C ratio; NHR, neutrophil-HDL-C ratio; OR, odds ratio; PHR, platelet-HDL-C ratio.