Table 3.
Association of LHR, MHR, NHR, and LHR with the prevalence of significant liver fibrosis in US adults
| Crude model OR (95% CI) P value | Model 1 OR (95% CI) P value | Model 2 OR (95% CI) P value | |
| Log2(LHR) | 1.840 (1.616–2.096) <0.0001 | 1.926 (1.691–2.193) <0.0001 | 1.570 (1.366–1.804) <0.0001 |
| LHR quartile | |||
| Q1 | Ref. | Ref. | Ref. |
| Q2 | 1.045 (0.643–1.700) 0.8593 | 1.115 (0.691–1.799) 0.6589 | 0.955 (0.577–1.581) 0.8601 |
| Q3 | 2.050 (1.570–2.677) <0.0001 | 2.194 (1.732–2.780) <0.0001 | 1.738 (1.384–2.181) 0.0001 |
| Q4 | 2.595 (1.915–3.516) <0.0001 | 2.839 (2.143–3.760) <0.0001 | 2.057 (1.508–2.805) 0.0002 |
| P for trend | <0.0001 | <0.0001 | <0.0001 |
| Log2(MHR) | 1.883 (1.506–2.356) <0.0001 | 1.803 (1.383–2.349) 0.0001 | 1.425 (1.068–1.901) 0.0249 |
| MHR quartile | |||
| Q1 | Ref. | Ref. | Ref. |
| Q2 | 1.766 (1.250–2.496) 0.0027 | 1.719 (1.210–2.441) 0.0054 | 1.389 (0.957–2.016) 0.0992 |
| Q3 | 2.212 (1.455–3.361) 0.0007 | 2.078 (1.312–3.291) 0.0043 | 1.612 (0.990–2.624) 0.0694 |
| Q4 | 3.235 (2.184–4.792) <0.0001 | 2.956 (1.873–4.665) 0.0001 | 1.923 (1.167–3.166) 0.0183 |
| P for trend | <0.0001 | 0.0001 | 0.0244 |
| Log2(NHR) | 1.855 (1.499–2.297) <0.0001 | 1.818 (1.422–2.323) <0.0001 | 1.396 (1.057–1.844) 0.0283 |
| NHR quartile | |||
| Q1 | Ref. | Ref. | Ref. |
| Q2 | 0.773 (0.524–1.140) 0.2015 | 0.760 (0.504–1.147) 0.2024 | 0.650 (0.425–0.994) 0.0609 |
| Q3 | 1.627 (1.208–2.191) 0.0028 | 1.582 (1.142–2.189) 0.0102 | 1.174 (0.825–1.669) 0.3832 |
| Q4 | 2.780 (1.983–3.897) <0.0001 | 2.644 (1.812–3.856) <0.0001 | 1.642 (1.072–2.516) 0.0337 |
| P for trend | <0.0001 | <0.0001 | 0.0017 |
| Log2(PHR) | 1.746 (1.397–2.182) <0.0001 | 1.823 (1.418–2.344) 0.0001 | 1.384 (1.057–1.813) 0.0276 |
| PHR quartile | |||
| Q1 | Ref. | Ref. | Ref. |
| Q2 | 0.969 (0.705–1.331) 0.8451 | 0.969 (0.708–1.327) 0.8469 | 0.761 (0.545–1.062) 0.1243 |
| Q3 | 1.329 (0.955–1.850) 0.1002 | 1.359 (0.983–1.880) 0.0741 | 0.995 (0.686–1.445) 0.9799 |
| Q4 | 2.273 (1.619–3.192) <0.0001 | 2.377 (1.635–3.455) 0.0001 | 1.527 (1.026–2.272) 0.0500 |
| P for trend | <0.0001 | <0.0001 | 0.0121 |
CI, confidence interval; LHR, lipoprotein-cholesterol ratio; MHR, monocyte-HDL-C ratio; NHR, neutrophil-HDL-C ratio; OR, odds ratio; PHR, platelet-HDL-C ratio.
The crude model was not adjusted for any covariates. Model 1 was partially adjusted for age, sex, race/ethnicity, education level, poverty income ratio (PIR), and marital status, whereas Model 2 additionally adjusted for smoking, physical activity, dietary energy intake, diabetes, hypertension, and BMI in addition to Model 1.