Table 1. Enzyme inhibition results of novel compounds 10a–n against AChE, BChE and alpha glucosidase.

Compound	R	IC50 (nM)
		AChE	BChE	α-Glucosidase
10a	2-Me	163.30 ± 5.38	18.43 ± 3.09	43.09 ± 8.21
10b	3-Me	166.80 ± 9.46	18.28 ± 4.84	62.09 ± 5.43
10c	4-Me	164.23 ± 9.70	17.12 ± 3.21	66.98 ± 7.88
10d	2,3-Dimethyl	131.01 ± 7.23	14.95 ± 2.08	71.19 ± 8.14
10e	2,4-Dimethoxy	139.76 ± 9.43	16.28 ± 2.09	58.45 ± 4.27
10f	4-Et	159.43 ± 6.17	17.02 ± 5.46	66.39 ± 4.43
10g	2-F	112.23 ± 9.60	12.43 ± 3.21	56.66 ± 6.34
10h	2-Cl	118.43 ± 9.17	19.43 ± 0.65	23.90 ± 3.42
10i	3-Cl	163.74 ± 9.54	15.32 ± 3.16	45.84 ± 4.71
10j	4-Cl	145.08 ± 6.23	16.43 ± 4.43	34.32 ± 3.49
10k	2,4-Dichloro	105.24 ± 7.32	10.11 ± 1.08	46.12 ± 3.26
10l	4-Br	148.19 ± 8.23	16.45 ± 4.74	39.13 ± 5.10
10m	2-Nitro	156.76 ± 8.65	16.91 ± 4.83	36.62 ± 4.86
10n	4-Nitro	172.91 ± 9.71	13.90 ± 4.30	65.09 ± 6.01
Tacrine	—	160.87 ± 6.20	58.03 ± 9.80	—
Donepezil	—	32.87 ± 2.16	>1000	—
Acarbose	—	—	—	60.57 ± 5.78