TABLE 1.
Cohort characteristics stratified by age-sex category
| Characteristics | Women ≤50 y (N = 12) | Women >50 y (N = 10) | Men ≤50 y (N = 18) | Men >50 y (N = 26) |
|---|---|---|---|---|
| Race, n (%) | ||||
| Asian | 0 (0.0) | 0 (0.0) | 2 (11.1) | 2 (7.7) |
| Black | 1 (8.3) | 1 (10.0) | 1 (5.6) | 1 (3.8) |
| White | 11 (91.7) | 9 (90.0) | 15 (83.3) | 23 (88.5) |
| Age at transplant, mean (SD) | 37.58 (10.32) | 59.71 (7.00) | 40.75 (6.91) | 62.19 (6.33) |
| Organ transplant type, n (%) | ||||
| Heart | 8 (66.7) | 6 (60.0) | 7 (38.9) | 19 (73.1) |
| Kidney | 4 (33.3) | 4 (40.0) | 10 (55.6) | 5 (19.2) |
| Deceased donor | 0 (0.0) | 0 (0.0) | 1 (10.0) | 0 (0.0) |
| Living unrelated donor | 2 (50.0) | 2 (50.0) | 8 (80.0) | 4 (80.0) |
| Living related donor | 2 (50.0) | 2 (50.0) | 1 (10.0) | 1 (20.0) |
| Heart-kidney | 0 (0.0) | 0 (0.0) | 1 (5.6) | 2 (7.7) |
| Pretransplant dialysis among kidney recipients, n (%) | ||||
| None | 2 (50.0) | 2 (50.0) | 4 (36.4) | 5 (71.4) |
| Hemodialysis | 1 (25.0) | 2 (50.0) | 6 (54.5) | 1 (14.3) |
| Peritoneal dialysis | 1 (25.0) | 0 (0.0) | 1 (9.1) | 1 (14.3) |
| Duration of pretransplant dialysis among kidney recipients (%) | ||||
| <1 y | 1 (50.0) | 1 (50.0) | 4 (57.1) | 1 (50.0) |
| 1–2 y | 1 (50.0) | 0 (0.0) | 0 (0.0) | 1 (50.0) |
| >2 y | 0 (0.0) | 1 (50.0) | 3 (42.9) | 0 (0.0) |
| Female donor (%) | 7 (58.3) | 9 (90.0) | 9 (50.0) | 5 (19.2) |
| Cytomegalovirus sero-status risk group, n (%) | ||||
| Low risk | 6 (50.0) | 3 (30.0) | 10 (55.6) | 6 (23.1) |
| Intermediate risk | 5 (41.7) | 6 (60.0) | 3 (16.7) | 9 (34.6) |
| High risk | 1 (8.3) | 1 (10.0) | 5 (27.8) | 11 (42.3) |
| BMI, mean (SD) | 29.30 (6.24) | 25.83 (4.82) | 29.49 (6.16) | 27.05 (4.94) |
| No. of prior pregnancies, mean (SD) | 2.17 (1.85) | 2.22 (1.72) | – | – |
| Postmenopausal,a n (%) | 0 (0.0) | 9 (90.0) | – | – |
| History of diabetes mellitus, n (%) | 1 (8.3) | 1 (10.0) | 4 (22.2) | 13 (50.0) |
| History of chronic kidney disease, n (%) | 5 (41.7) | 7 (70.0) | 12 (66.7) | 17 (65.4) |
| cPRA, mean (SD) | 39.25 (43.05) | 17.20 (24.88) | 6.71 (17.08) | 4.54 (9.49) |
| Baseline laboratory measurements, mean (SD) | ||||
| WBC | 8.80 (5.46) | 8.55 (5.23) | 8.49 (4.41) | 9.21 (1.81) |
| ANC | 5.86 (3.85) | 6.42 (5.09) | 5.59 (2.86) | 6.79 (1.79) |
| ALC | 1.79 (0.95) | 1.24 (0.45) | 1.74 (1.46) | 1.06 (0.46) |
| CD4+ | 0.92 (0.49) | 0.65 (0.28) | 0.71 (0.26) | 0.48 (0.18) |
| CD8+ | 0.43 (0.23) | 0.29 (0.22) | 0.38 (0.24) | 0.25 (0.22) |
| CD4:CD8 ratio | 2.16 (0.52) | 2.81 (1.88) | 2.30 (1.14) | 2.98 (2.14) |
| CD3+ | 1.39 (0.74) | 0.95 (0.44) | 1.13 (0.49) | 0.74 (0.35) |
| IgG | 1035.25 (321.04) | 985.90 (322.86) | 1143.83 (340.97) | 1114.92 (421.13) |
| eGFRb | 58.33 (43.26) | 37.70 (35.14) | 35.78 (44.17) | 52.15 (30.61) |
| Induction immunosuppression, n (%) | 8 (66.7) | 5 (50.0) | 12 (66.7) | 13 (50.0) |
| Type of induction, n (%) | ||||
| None | 4 (33.3) | 5 (50.0) | 6 (33.3) | 13 (50.0) |
| Basiliximab | 2 (16.7) | 2 (20.0) | 4 (22.2) | 8 (30.8) |
| Antithymocyte globulin | 6 (50.0) | 3 (30.0) | 8 (44.4) | 5 (19.2) |
aOne woman who was amenorrheic before transplant and had categorized herself as postmenopausal was recategorized when regular menstruation returned after a kidney transplant.
bCalculated according to the CKD-EPI equation based on serum creatinine.39
ALC, absolute lymphocyte count; ANC, absolute neutrophil count; BMI, body mass index; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; cPRA, calculated panel-reactive antibody; eGFR, estimated glomerular filtration rate; WBC, white blood cell count.