. 2025 Aug 19;15(36):29201–29216. doi: 10.1039/d5ra05372b

Table 1. Half-maximal inhibitory concentrations (IC₅₀) of the four resin acids against human CA IX, CA I and CA II measured by stopped-flow CO₂-hydrase assay (pH 7.4, 25 °C). Values are mean ± SD (n = 3).

Compound	IC₅₀ (nM) hCA IX	IC₅₀ (μM) hCA I	IC₅₀ (μM) hCA II	S _I ^a	S _II ^b
Callitrisic acid	93.35 ± 1.65	1.35 ± 0.11	0.52 ± 0.04	14.5	5.6
Levopimaric acid	147.59 ± 4.7	1.50 ± 0.12	0.68 ± 0.05	10.2	4.6
Palustric acid	290.46 ± 15.7	2.25 ± 0.20	1.45 ± 0.12	7.8	5.0
Pimaric acid	340.7 ± 6.37	2.70 ± 0.25	1.62 ± 0.13	7.9	4.8

S _I = (IC₅₀ hCA I, nM)/(IC₅₀ hCA IX, nM).

S _II = (IC₅₀ hCA II, nM)/(IC₅₀ hCA IX, nM).

Table 1. Half-maximal inhibitory concentrations (IC50) of the four resin acids against human CA IX, CA I and CA II measured by stopped-flow CO2-hydrase assay (pH 7.4, 25 °C). Values are mean ± SD (n = 3).