Table 1. Macrophage functions and pathways regulated by post-transcriptional regulation.
| Post-transcriptional Process | Pathway or Function | Refs |
|---|---|---|
| Alternative Splicing | TLRs, MyD88, MD2, Type I Interferon Response, IL-6, Mtb Infection |
[13,14,16–18,59,63,64,70,71,74] |
| Alternative Cleavage | TLRs, RIG-I, TNF-α, SARS CoV-2 Antiviral Response | [21–24, 0] |
| mTOR Regulation of Translation Initiation and Elongation | Phagocytosis, Chemotaxis, Type II Interferon Response, Immunosupression |
[26–28] |
| Inhibition of Translation Initiation by the Integrated Stress Response | Inflammasome Activation, PRR Sensing, Immunosupression | [31–33] |
| Regulation of mRNA stability | IL-6, TNF-α, OAS, Autoimmunity | [44,47,54,58,82] |